Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Surgical treatment of moderate and severe ptosis: analysis of results
, 2018 Rodolfo Chedid +2 more
openalex +1 more source
Surgical Treatment of Benign Retrorectal Masses in Adults: A Retrospective Study
, 2021 Hüseyin Bilge +2 more
openalex +2 more sources
Non‐surgical peri‐implantitis treatment using a pocket irrigator device; clinical, microbiological, radiographical and patient‐centred outcomes—A pilot study [PDF]
, 2020 Diederik F. M. Hentenaar +4 more
openalex +1 more source
Validation of uterine artery embolization before surgical laparoscopic myomenucleation compared to single surgical laparoscopic myomenucleation for the treatment of large fibroids and uterus myomatosus [PDF]
, 2023 Stefan Hertling +2 more
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Surgical Treatment of Aortic Arch Branch Aneurysms.
, 1993 Ichiro Morita +6 more
openalex +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Long-term outcomes of surgical treatment of common ovarian cancer at the stage of primary debulking
, 2019 M. N. Sekerskaya +5 more
openalex +2 more sources