Results 71 to 80 of about 2,669,426 (245)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Low-cost wound protector for laparoscopic surgeries [PDF]

Revista do Colégio Brasileiro de Cirurgiões
The role of wound protectors in laparoscopic surgeries is highly controversial in the literature. Some studies demonstrate their benefit in reducing the rate of surgical site infections; however, these results are not reproducible across all procedures ...
CARLOS AUGUSTO METIDIERI MENEGOZZO, CRISTIANE PRESTES DA ROSA OLIVEIRA, ROBERTO RASSLAN, FELIPE KFOURI, ALBERTO BITRAN, RENATO SILVEIRA LEAL, SERGIO HENRIQUE BASTOS DAMOUS, EDIVALDO MASSAZO UTIYAMA   +7 more
doaj   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The evidence and the rationale for the use of honey as wound dressing [PDF]

, 2011
Although there are now several brands and types of honey wound-care products available as registered medical devices, there is little promotional advertising of honey products for wound care. The misconception that there is no evidence to support the use
Molan, Peter C.
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

CUMULATIVE INCIDENCE AND FACTORS ASSOCIATED WITH SURGICAL SITE INFECTIONS IN A HOSPITAL COHORT (2011–2025)

Brazilian Journal of Infectious Diseases
Introduction/Objective: Surgical site infections (SSIs) are a relevant complication, with potential negative impacts on patient recovery and hospital costs. Their occurrence may be influenced by patient-related factors, the contamination potential of the
Gabriela Nagem de Aragão, Lafaiete Barboza da Cruz, Nayane Beatriz Machado Silva, Carlos Magno Castelo Branco Fortaleza, Gabriel Berg de Almeida   +4 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

SurgWound-Bench: a benchmark for surgical wound diagnosis

npj Digital Medicine
Surgical site infection (SSI) is one of the most common and costly healthcare-associated infections, and surgical wound care remains a significant challenge for preventing SSIs and improving patient outcomes.
Jiahao Xu, Changchang Yin, Odysseas P. Chatzipanagiotou, Diamantis I. Tsilimigras, Kevin Clear, Bingsheng Yao, Weidan Cao, Dakuo Wang, Timothy M. Pawlik, Ping Zhang   +9 more
doaj   +1 more source

A randomized controlled trial comparing large versus small stitch incision closure in gynaecological malignancies (CLaSSIC Study)

Cancer Treatment and Research Communications
Objective: The study aimed to compare Small Stitch Closure (SSC) and Large Stitch Closure (LSC) techniques for reducing incisional ventral hernia (IVH) and surgical site infection (SSI) rates in gynaecological malignancies. Methods: We conducted a single-
Priya Bhati, Monal Garg, Saumya Gupta, Hawwa Hana, Anandita Anandita, Sheejamol V S   +5 more
doaj   +1 more source