Results 61 to 70 of about 3,103,046 (298)

Surgical wound infection [PDF]

open access: yes, 1999
Objective. To review the risk factors for surgical would infection; the use of prophylactic antibiotics in the prevention of wound infection; and the benefits of wound surveillance programmes to reduce the rate of surgical wound infection.
Soundara Rajan, S   +4 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Low-cost wound protector for laparoscopic surgeries [PDF]

open access: yesRevista do Colégio Brasileiro de Cirurgiões
The role of wound protectors in laparoscopic surgeries is highly controversial in the literature. Some studies demonstrate their benefit in reducing the rate of surgical site infections; however, these results are not reproducible across all procedures ...
CARLOS AUGUSTO METIDIERI MENEGOZZO   +7 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

CUMULATIVE INCIDENCE AND FACTORS ASSOCIATED WITH SURGICAL SITE INFECTIONS IN A HOSPITAL COHORT (2011–2025)

open access: yesBrazilian Journal of Infectious Diseases
Introduction/Objective: Surgical site infections (SSIs) are a relevant complication, with potential negative impacts on patient recovery and hospital costs. Their occurrence may be influenced by patient-related factors, the contamination potential of the
Gabriela Nagem de Aragão   +4 more
doaj   +1 more source

Surgical wound assessment and documentation of nurses: an integrative review

open access: yes, 2016
Objective: Surgical site infections (SSI) are serious complications that can lead to adverse patient outcomes such as prolonged hospital length of stay, increased health-care costs, and even death.
Ding, S, Gillespie, BM, Lin, F
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SurgWound-Bench: a benchmark for surgical wound diagnosis

open access: yesnpj Digital Medicine
Surgical site infection (SSI) is one of the most common and costly healthcare-associated infections, and surgical wound care remains a significant challenge for preventing SSIs and improving patient outcomes.
Jiahao Xu   +9 more
doaj   +1 more source

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