Results 51 to 60 of about 209,946 (311)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The evidence supporting the use of honey as a wound dressing

, 2006
Some clinicians are under the impression that there is little or no evidence to support the use of honey as a wound dressing. This impression is reinforced by it being concluded in systematic reviews that the evidence is not of a high standard.
Molan, Peter C., P. C. Molan
core   +1 more source

Low-cost wound protector for laparoscopic surgeries [PDF]

Revista do Colégio Brasileiro de Cirurgiões
The role of wound protectors in laparoscopic surgeries is highly controversial in the literature. Some studies demonstrate their benefit in reducing the rate of surgical site infections; however, these results are not reproducible across all procedures ...
CARLOS AUGUSTO METIDIERI MENEGOZZO, CRISTIANE PRESTES DA ROSA OLIVEIRA, ROBERTO RASSLAN, FELIPE KFOURI, ALBERTO BITRAN, RENATO SILVEIRA LEAL, SERGIO HENRIQUE BASTOS DAMOUS, EDIVALDO MASSAZO UTIYAMA   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Using honey to heal diabetic foot ulcers

, 2008
Diabetic ulcers seem to be arrested in the inflammatory/proliferative stage of the healing process, allowing infection and inflammation to preclude healing.
Molan, Peter C., Betts, J.A.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Medical honey for wound care—Still the ‘Latest Resort’?

, 2008
While the ancient Egyptians and Greeks used honey for wound care, and a broad spectrum of wounds are treated all over the world with natural unprocessed honeys from different sources, Medihoney™ has been one of the first medically certified honeys ...
Santos, Kai, Molan, Peter C., Gisela Blaser, Udo Bode, Blaser, Gisela, Traynor, Kristen, Kai Santos, Bode, Udo, Kirsten Traynor, Simon, Arne, Arne Simon, Peter Molan   +11 more
core   +1 more source

CUMULATIVE INCIDENCE AND FACTORS ASSOCIATED WITH SURGICAL SITE INFECTIONS IN A HOSPITAL COHORT (2011–2025)

Brazilian Journal of Infectious Diseases
Introduction/Objective: Surgical site infections (SSIs) are a relevant complication, with potential negative impacts on patient recovery and hospital costs. Their occurrence may be influenced by patient-related factors, the contamination potential of the
Gabriela Nagem de Aragão, Lafaiete Barboza da Cruz, Nayane Beatriz Machado Silva, Carlos Magno Castelo Branco Fortaleza, Gabriel Berg de Almeida   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

A randomized controlled trial comparing large versus small stitch incision closure in gynaecological malignancies (CLaSSIC Study)

Cancer Treatment and Research Communications
Objective: The study aimed to compare Small Stitch Closure (SSC) and Large Stitch Closure (LSC) techniques for reducing incisional ventral hernia (IVH) and surgical site infection (SSI) rates in gynaecological malignancies. Methods: We conducted a single-
Priya Bhati, Monal Garg, Saumya Gupta, Hawwa Hana, Anandita Anandita, Sheejamol V S   +5 more
doaj   +1 more source