Results 41 to 50 of about 1,283,297 (306)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
A Dichotomic Analysis of the Surprise Examination Paradox [PDF]
, 2002 This paper presents a dichotomic analysis of the surprise examination paradox. In section 1, I analyse the surprise notion in detail. I introduce then in section 2, the distinction between a monist and dichotomic analysis of the paradox.
Franceschi, Paul
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Annals of Medical and Health Sciences Research, 2014 Melioidosis is a zoonosis caused by the accidental pathogen Burkholderia pseudomallei, which is endemic in Southeast Asia and northern Australia. The mortality of melioidosis is 20-50% even with treatment. Suppurative lymphadenitis caused by melioidosis has been rarely encountered by clinicians practicing in endemic areas. In the majority of previously
Jakribettu, RP +3 more
openaire +3 more sources
What's surprising about surprisal
, 2023 In the computational and experimental psycholinguistic literature, the mechanisms behind syntactic structure building (e.g., combining words into phrases and sentences) are the subject of considerable debate. Much experimental work has shown that surprisal is a good predictor of human behavioral and neural data. These findings have led some authors to
Sophie Slaats, Andrea E. Martin
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
E-Spania, 2017 Le sentiment d’admiration et d’étonnement, exprimé en castillan principalement par le verbe maravillar, est présent dans la chronique royale comme un motif rhétorique ; incorporé au récit, il peut mettre en évidence, dans la logique interne de la ...
David Nogales Rincón
doaj +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Situational Variability of Means of Expression of Positive Emotions in Modern English
Известия Южного федерального университета: Филологические науки, 2017 The article investigates situational variability of means of expression of positive emotions in Modern English. This problem is topical for linguistics of emotions, pragma- and sociolinguistics.
Alina K. Kisil
doaj +1 more source
The Aesthetic and Cognitive Value of Surprise [PDF]
, 2014 It is a common experience to be surprised by an artwork. In this paper, I examine how and why this obvious fact matters for philosophical aesthetics. Following recent works in psychology and philosophers such as Davidson or Scheffler, we will see that ...
Declos, Alexandre
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