Results 41 to 50 of about 203,988 (309)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Frontiers in Psychology, 2018 In this article we explore the relationship between learning and the conjunction fallacy. The interpretation of the conjunction effect as a fallacy assumes that all observers share the same knowledge, and that nobody has access to privileged information.
Phil Maguire +3 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Dichotomic Analysis of the Surprise Examination Paradox [PDF]
, 2005 This paper proposes a new framework to solve the surprise examination paradox. I survey preliminary the main contributions to the literature related to the paradox. I introduce then a distinction between a monist and a dichotomic analysis of the paradox.
Franceschi, Paul
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
What is value – accumulated reward or evidence?
Frontiers in Neurorobotics, 2012 Why are you reading this abstract? In some sense, your answer will cast the exercise as valuable – but what is value? In what follows, we suggest that value is evidence or, more exactly, log Bayesian evidence.
Karl eFriston +2 more
doaj +1 more source
Surprise Acts as a Reducer of Outcome Value in Human Reinforcement Learning
Frontiers in Neuroscience, 2020 Surprise occurs because of differences between a decision outcome and its predicted outcome (prediction error), regardless of whether the error is positive or negative.
Motofumi Sumiya +2 more
doaj +1 more source
The Surprise Examination Paradox and the Second Incompleteness Theorem [PDF]
, 2010 We give a new proof for Godel's second incompleteness theorem, based on Kolmogorov complexity, Chaitin's incompleteness theorem, and an argument that resembles the surprise examination paradox.
Raz, Ran, Kritchman, Shira
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, 2021 In diesem #Podcast nehmen wir Sie mit in den #Kaukasus, nach Armenien. Dort hat unsere Autorin Manon Borel Menschen getroffen, die nach 2011 aus Syrien in die Republik im Südkaukasus flüchteten – und nun durch den Konflikt um #Bergkarabach am Ort ihrer ...
Borel, Manon
core