Results 71 to 80 of about 372,297 (338)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Das Zufluchtsland wird Konfliktgebiet
, 2021 Cover story on Syrian-Armenians in Armenia in the aftermath of the War in ...
Borel, Manon
core +1 more source
Pupil diameter encodes the idiosyncratic, cognitive complexity of belief updating
eLife, 2020 Pupils tend to dilate in response to surprising events, but it is not known whether these responses are primarily stimulus driven or instead reflect a more nuanced relationship between pupil-linked arousal systems and cognitive expectations.
Alexandre LS Filipowicz +3 more
doaj +1 more source
Multiscale Free Energy Analysis of Human Ecosystem Engineering
Entropy, 2021 Unlike ecosystem engineering by other living things, which brings a relatively limited range of sensations that are connected to a few enduring survival preferences, human ecosystem engineering brings an increasing variety and frequency of novel ...
Stephen Fox
doaj +1 more source
“Surprise” and the Bayesian Brain: Implications for Psychotherapy Theory and Practice
Frontiers in Psychology, 2019 The free energy principle (FEP) has gained widespread interest and growing acceptance as a new paradigm of brain function, but has had little impact on the theory and practice of psychotherapy. The aim of this paper is to redress this.
J. Holmes, T. Nolte
semanticscholar +1 more source
A Dichotomic Analysis of the Surprise Examination Paradox [PDF]
, 2005 This paper proposes a new framework to solve the surprise examination paradox. I survey preliminary the main contributions to the literature related to the paradox. I introduce then a distinction between a monist and a dichotomic analysis of the paradox.
Franceschi, Paul
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Frontiers in Psychology, 2018 When people retell stories, what guides their retelling? Most previous research on story retelling and story comprehension has focused on information accuracy as the key measure of stability in transmission.
Fritz Breithaupt +7 more
doaj +1 more source
Circulation, 2012 Baruteau and colleagues1 present findings that further the potential for a genetic basis for nonimmune isolated atrioventricular (AV) block. Their observations warrant further consideration in the evaluation and management of patients with no definitive cause of their cardiac conduction defect.
Bryan C, Cannon, Michael J, Ackerman
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source