Results 91 to 100 of about 24,751,639 (251)

Collaborative optimization method of surrogate model for ship cabin structure based on sub-model decomposition

Zhongguo Jianchuan Yanjiu
ObjectivesIn order to solve the difficulties of numerous design parameters and time-consuming computation of ship cabin structure optimization, a collaborative optimization method of surrogate model for cabin structure based on sub-model decomposition is
Junze WANG, Pan ZHANG, Jun LIU, Yuansheng CHENG   +3 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Coupled simulation-optimization model for coastal aquifer management using genetic programming-based ensemble surrogate models and multiple-realization optimization [PDF]

, 2011
Approximation surrogates are used to substitute the numerical simulation model within optimization algorithms in order to reduce the computational burden on the coupled simulation-optimization methodology.
Sreekanth, J., Datta, Bithin, J. Sreekanth, Bithin Datta   +3 more
core   +1 more source

Hybrid genetic algorithm with a GNN-based surrogate model for pipe support design optimization in nuclear power plant

Nuclear Engineering and Technology
Pipe support design for nuclear power plant piping systems is traditionally performed through iterative piping stress analyses based on engineering experience, requiring significant time and effort.
Daeyoung Jeong, Sungryul Kim
doaj   +1 more source

Structural optimization of an underwater glider with blended wing body

Advances in Mechanical Engineering, 2017
This article deals with the mass estimation of an underwater glider with blended wing body subject to multiple constraints including strength, deformation, and stability in order to maximize its payload capacity and long range. Parametric modeling of the
Yanru He, Baowei Song, Yonghui Cao
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Data-Driven Interactive Multiobjective Optimization Using a Cluster-Based Surrogate in a Discrete Decision Space

, 2019
In this paper, a clustering based surrogate is proposed to be used in offline data-driven multiobjective optimization to reduce the size of the optimization problem in the decision space.
Kyle Eyvindson, Malmberg, Jose, Ojalehto, Vesa, Hakanen, Jussi, Vesa Ojalehto, Eyvindson, Kyle, Jussi Hakanen, Jose Malmberg   +7 more
core   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Surrogate-Assisted Evolutionary Optimization of Large Problems

, 2019
This chapter presents some recent advances in surrogate-assisted evolutionary optimization of large problems. By large problems, we mean either the number of decision variables is large, or the number of objectives is large, or both.
Handing Wang, Chugh, Tinkle, Chaoli Sun, Yaochu Jin, Jin, Yaochu, Sun, Chaoli, Wang, Handing, Tinkle Chugh   +7 more
core   +1 more source