Results 81 to 90 of about 24,751,639 (251)

Surrogate-based Optimization of Capture Chromatography Platforms for the Improvement of Computational Efficiency. [PDF]

Comput Chem Eng, 2023
Romero JJ, Jenkins EW, Husson SM.
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Surrogate Models and Ensemble Strategies for Expensive Evolutionary Optimization: An Industrial Case Study

IEEE Access
Expensive optimization problems are characterized by the significant amount of time and resources needed to determine the quality of potential solutions.
Mario Garza-Fabre, Nicolas Cortes-Garcia, Hiram Galeana-Zapien, Ricardo Landa   +3 more
doaj   +1 more source

A Transfer Learning Based Dual-Surrogate-Assisted Hull Form Optimization Method [PDF]

Jisuanji gongcheng
In the surrogate-assisted optimization of expensive objective functions, obtaining enough samples is time-consuming in fluid simulations. This paper proposes a Transfer Learning based Dual-Surrogate-Assisted hull form Optimization (TLDSAO) algorithm to ...
AN Chang, MAO Li
doaj   +1 more source

Enhancement of Mixing Performance of Two-Layer Crossing Micromixer through Surrogate-Based Optimization. [PDF]

Micromachines (Basel), 2021
Hossain S, Tayeb NT, Islam F, Kaseem M, Bui PDH, Bhuiya MMK, Aslam M, Kim KY.   +7 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Higher-order factorization machine for accurate surrogate modeling in material design

Scientific Reports
Efficient and robust optimization is important in material science for identifying optimal structural parameters and enhancing material performance. Surrogate-based active learning algorithms have recently gained great attention for their ability to ...
Sanghyo Hwang, Seongmin Kim, Zhihao Xu, Tengfei Luo, Eungkyu Lee   +4 more
doaj   +1 more source

A Multi-Fidelity Kriging-Based Experiment Optimization Framework with an Augmented Lagrangian Method for Distributed Optimal Design

Aerospace
Distributed optimal design brings significant solutions for experiment optimization in complex engineering design problems. A Kriging-based augmented Lagrangian Method is proposed with the help of the Multi-fidelity Hamiltonian Kriging (MHK) surrogate ...
Shixuan Zhang, Jie Ma
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source