Results 31 to 40 of about 24,751,639 (251)
Surrogate-based optimization method with adaptive sampling
, 2018 In a typical engineering design workflow, optimization is a highly iterative process, requiring several evaluations of the performance of the item that is being designed. The main goal of the design workflow is to create a cost-effective solution that is
Aldo Rona (7583084) +1 more
core +4 more sources
DADOS: A Cloud-based Data-driven Design Optimization System
Chinese Journal of Mechanical Engineering, 2023 This paper presents a cloud-based data-driven design optimization system, named DADOS, to help engineers and researchers improve a design or product easily and efficiently.
Xueguan Song +4 more
doaj +1 more source
Radiation shielding optimization based on dynamic radial basis surrogate model of particle flight
He jishuBackgroundRadiation shielding is crucial for ensuring the environmental safety of personnel and nuclear facilities in the nuclear industry. As it usually consumes a long time in single simulation calculation, the optimization design of radiation ...
GAO Shuai +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling +2 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
A framework for surrogate-based aerodynamic optimization [PDF]
, 2011 At DLR, an optimization framework combining different CFD solvers, Design of Experiment methods, optimization algorithms, and various surrogate modeling methodologies with sample refinement strategies for efficient surrogate-based global optimization is ...
Görtz, Stefan +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Journal of Petroleum Exploration and Production TechnologySurrogate-assisted management of water-flooding, as a reservoir production optimization strategy, dynamically adjusts development schemes at each production step, leading to improved economic benefits and enhanced recovery.
Lian Wang +9 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Results in EngineeringThis paper proposes a hybrid AI-assisted optimization framework for delayed vibration suppression based on the H 2 -smoothed spectral abscissa. A local neural-network (NN) surrogate approximates the high-fidelity objective to enable efficient candidate ...
Feleke Tsegaye Yareshe +4 more
doaj +1 more source