Results 41 to 50 of about 24,751,639 (251)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Surrogate-based agents for constrained optimization [PDF]

, 2012
http://www.emse.fr/~picard/publications/villanueva12ndac.pdfInternational audienceMulti-agent systems have been used to solve complex problems by decomposing them into autonomous subtasks.
Haftka, Raphael, T., Diane Villanueva, Gauthier Picard, Raphael Haftka, Picard, Gauthier, Raphael T. Haftka, Le Riche, Rodolphe, Rodolphe Le Riche, Villanueva, Diane   +8 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Surrogate-assisted evolutionary optimization frameworks for high-fidelity engineering design problems [PDF]

, 2004
Over the last decade, Evolutionary Algorithms (EAs) have emerged as a powerful paradigm for global optimization of multimodal functions. More recently, there has been significant interest in applying EAs to engineering design problems.
Wong, K.W., Ong, Yew Soon, Keane, A.J., Nair, P.B., Ong, Y.S.   +4 more
core  

Volute Optimization Based on Self-Adaption Kriging Surrogate Model

International Journal of Chemical Engineering, 2022
Optimizing the volute performance can effectively improve the efficiency of a centrifugal fan by changing the volute geometric parameter, so the self-adaption Kriging surrogate model is used to optimize the volute geometric parameter.
Fannian Meng, Ziqi Zhang, Liangwen Wang
doaj   +1 more source

A Transformation-Based Improved Kriging Method for the Black Box Problem in Reliability-Based Design Optimization

Mathematics, 2023
In order to overcome the drawbacks of expensive function evaluation in the practical reliability-based design optimization (RBDO) problem, researchers have proposed the black box-based RBDO method.
Li Lu, Yizhong Wu, Qi Zhang, Ping Qiao
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Parallel Space-Mapping Based Yield-Driven EM Optimization Incorporating Trust Region Algorithm and Polynomial Chaos Expansion

IEEE Access, 2019
Space mapping (SM) methodology has been recognized as a powerful tool for accelerating electromagnetic (EM)-based yield optimization. This paper proposes a novel parallel space-mapping based yield-driven EM optimization technique incorporating trust ...
Jianan Zhang, Feng Feng, Weicong Na, Shuxia Yan, Qijun Zhang   +4 more
doaj   +1 more source

An efficient geometric constraint handling method for surrogate-based aerodynamic shape optimization

Engineering Applications of Computational Fluid Mechanics, 2023
Handling a large number of geometric constraints brings a big challenge to the surrogate-based aerodynamic shape optimization (ASO) driven by computational fluid dynamics (CFD).
Kai Wang, Zhong-Hua Han, Ke-Shi Zhang, Wen-Ping Song   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source