Results 51 to 60 of about 24,751,639 (251)

Considerations of Accuracy and Uncertainty with Kriging Surrogate Models in Single-Objective Electromagnetic Design Optimization

, 2007
The high computational cost of evaluating objective functions in electromagnetic optimal design problems necessitates the use of cost-effective techniques.
Hawe, G., Sykulski, J.K.
core   +1 more source

Multidisciplinary design optimization of non-uniform stiffened cylindrical shells

Zhongguo Jianchuan Yanjiu, 2021
ObjectivesUnderwater structures have strict requirements for intensity, mass, vibration, noise and so on. From a multidisciplinary perspective, realizing the design optimization of such structures to improve their overall performance is of great ...
Jingru LI, Jiang LIU, Sheng LI
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

HIGH SPEED FUNCTIONALITY OPTIMIZATION OF FIVE-PHASE PM MACHINE USING 3RD HARMONIC CURRENT [PDF]

, 2013
This project was supported by the Laboratory of Electrical Engineering and Power Electronics (L2EP) France. It is a successive cooperation project between the control team and optimization team of the laboratory .Some surrogate-assisted optimization ...
GONG, Jinlin, ASLAN, Bassel, SEMAIL, Eric, GONG, Jilin, GILLON, Frédéric   +4 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Impacts of Problem Scale and Sampling Strategy on Surrogate Model Accuracy An Application of Surrogate-based Optimization in Building Design

, 2016
Surrogate-based Optimization is a useful approach when the objective function is computationally expensive to evaluate, compared to Simulation-based Optimization.
Di Stefano, D., Turrin, M., Yang, D., Sariyildiz, I.S., Sun, Y.M.   +4 more
core   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Groundwater Pollution Source Identification via an Integrated Surrogate Model and Multiobjective Heuristic Optimization Algorithms

Water Resources Research
Simulation‐optimization methods are commonly used in groundwater pollution source identification. Traditional simulation‐optimization methods require multiple calls to the numerical model, which leads to a considerable computational burden.
Shengjie Hu, Zuorong Xu, Rui Zuo, Jingchao Liu   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Multiobjective optimization using surrogates

, 2006
Until recently, optimization was regarded as a discipline of rather theoretical interest, with limited real-life applicability due to the comutational or experimental expense involved.
Keane, A.J., Voutchkov, I.
core   +1 more source