Results 81 to 90 of about 133,335 (273)

Multi-Objective Optimization Method for Comprehensive Modification of High-Contact-Ratio Asymmetrical Planetary Gear Based on Hybrid Surrogate Model

Machines
The contact performance of high-contact-ratio asymmetrical planetary gears is comprehensively evaluated using multiple indicators. The relationship between the indicators and modification parameters is difficult to accurately describe with a single type ...
Yuansheng Zhou, Zhongwei Tang, Bingquan Lu, Jinyuan Tang, Shaoxue Wei   +4 more
doaj   +1 more source

RF cavity design exploiting a new derivative-free trust region optimization approach

Journal of Advanced Research, 2015
In this article, a novel derivative-free (DF) surrogate-based trust region optimization approach is proposed. In the proposed approach, quadratic surrogate models are constructed and successively updated.
Abdel-Karim S.O. Hassan, Hany L. Abdel-Malek, Ahmed S.A. Mohamed, Tamer M. Abuelfadl, Ahmed E. Elqenawy   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A Transfer Learning Based Dual-Surrogate-Assisted Hull Form Optimization Method [PDF]

Jisuanji gongcheng
In the surrogate-assisted optimization of expensive objective functions, obtaining enough samples is time-consuming in fluid simulations. This paper proposes a Transfer Learning based Dual-Surrogate-Assisted hull form Optimization (TLDSAO) algorithm to ...
AN Chang, MAO Li
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

KL-based Control of the Learning Schedule for Surrogate Black-Box Optimization [PDF]

, 2013
This paper investigates the control of an ML component within the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) devoted to black-box optimization.
Loshchilov, Ilya, Schoenauer, Marc, Sebag, Michèle   +2 more
core   +3 more sources

Data-Driven Combined State and Parameter Reduction for Extreme-Scale Inverse Problems

, 2014
In this contribution we present an accelerated optimization-based approach for combined state and parameter reduction of a parametrized linear control system which is then used as a surrogate model in a Bayesian inverse setting. Following the basic ideas
Himpe, Christian, Ohlberger, Mario
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Structural optimization of an underwater glider with blended wing body

Advances in Mechanical Engineering, 2017
This article deals with the mass estimation of an underwater glider with blended wing body subject to multiple constraints including strength, deformation, and stability in order to maximize its payload capacity and long range. Parametric modeling of the
Yanru He, Baowei Song, Yonghui Cao
doaj   +1 more source