Results 11 to 20 of about 79,600 (335)

Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more [PDF]

BMJ Oncology
Clinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tumour growth, tumour shrinkage, blood results, etc ...
Vinay Prasad, Alyson Haslam, Timothée Olivier, Dagney Ochoa, Eduardo Fernandez   +4 more
doaj   +2 more sources

Reply to Di Nunno et al. concerning objective response rates targets for recurrent glioblastoma clinical trials: Toward surrogate endpoints for phase II trials in patients with recurrent glioblastoma. [PDF]

Neuro Oncol, 2023
Ellingson BM, Wen PY, Cloughesy TF.
europepmc   +3 more sources

Correlation between surrogate endpoints and overall survival in unresectable hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis [PDF]

Scientific Reports
This study aimed to assess the therapeutic effect of immune checkpoint inhibitors (ICIs) in patients with unresectable hepatocellular carcinoma (uHCC) and investigate the correlation between surrogate endpoints and overall survival (OS).
Litao Huang, Deying Kang, Chongyang Zhao, Xueting Liu   +3 more
doaj   +2 more sources

The Validity of Surrogate Endpoints in Sub Groups of Metastatic Colorectal Cancer Patients Defined by Treatment Class and KRAS Status. [PDF]

Cancers (Basel), 2022
Poad H, Khan S, Wheaton L, Thomas A, Sweeting M, Bujkiewicz S.   +5 more
europepmc   +3 more sources

Surrogate endpoints for neonatal outcome: A rapid review [PDF]

Health Science Reports
Shiraz El Adam, Karissa Johnston, Maanasa Venkataraman, Vanessa Perez Patel   +3 more
doaj   +2 more sources

Endpoints: types, selection, interpretation of the results obtained on the example of cardiology studies

Кардиоваскулярная терапия и профилактика, 2022
The importance of high-quality randomized controlled trials cannot be overemphasized. Each such study attempts to answer a specific clinical question. To do this, it is necessary to determine in advance the indicator of achievement of a specific result ...
A. R. Navasardyan, S. Yu. Martsevich
doaj   +1 more source

true endpoint, surrogate endopoint

Journal of JCS Cardiologists, 2001
林 同文
openaire   +3 more sources

Reply to Commentary by Cummings (2022): Surrogate endpoints extend beyond biomarkers [PDF]

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Anthony Muchai Manyara, Oriana Ciani, Rod S. Taylor   +2 more
doaj   +2 more sources

Patient Centered Outcomes in Periodontal Treatment-An Evidenced Based Approach [PDF]

Journal of Clinical and Diagnostic Research, 2017
Transformation of research into clinical practice is the most challenging step in evidence based dental practice. Designing the most reliable research with applicable endpoint evaluation is very important as it can lead to successful research outcomes ...
Ekta Bharatbhai Shah, Bhavesh Bhupendrabhai Modi, Monali Amit Shah, Deepak Harishbhai Dave   +3 more
doaj   +1 more source

Incorporating Covariates into Measures of Surrogate Paradox Risk

Stats, 2023
Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani, Jeremy M. G. Taylor, Niko Kaciroti, Michael R. Elliott   +3 more
doaj   +1 more source