Results 11 to 20 of about 277,103 (274)
BMJ Open, 2022 Introduction Randomised controlled trials (RCTs) may use surrogate endpoints as substitutes and predictors of patient-relevant/participant-relevant final outcomes (eg, survival, health-related quality of life).
Martin Offringa +10 more
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Use of surrogate endpoints in health technology assessment and reimbursement of treatments for the management of chronic kidney disease [PDF]
EClinicalMedicineSummary: The judicious use of surrogate endpoints as substitutes for patient relevant target outcomes can substantially reduce the size and duration of clinical trials, thereby driving down research and development costs and driving faster patient access
Rod S. Taylor +9 more
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The Evaluation of Surrogate Endpoints
, 2005 Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies.
Molenberghs, Geert +2 more
core +3 more sources
Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more [PDF]
BMJ OncologyClinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tumour growth, tumour shrinkage, blood results, etc ...
Vinay Prasad +4 more
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Кардиоваскулярная терапия и профилактика, 2022 The importance of high-quality randomized controlled trials cannot be overemphasized. Each such study attempts to answer a specific clinical question. To do this, it is necessary to determine in advance the indicator of achievement of a specific result ...
A. R. Navasardyan, S. Yu. Martsevich
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Surrogate endpoints for neonatal outcome: A rapid review [PDF]
Health Science ReportsShiraz El Adam +3 more
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Patient Centered Outcomes in Periodontal Treatment-An Evidenced Based Approach [PDF]
Journal of Clinical and Diagnostic Research, 2017 Transformation of research into clinical practice is the most challenging step in evidence based dental practice. Designing the most reliable research with applicable endpoint evaluation is very important as it can lead to successful research outcomes ...
Ekta Bharatbhai Shah +3 more
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The perils of surrogate endpoints [PDF]
European Heart Journal, 2015 Our goals in medicine are (i) to improve the quality of patients' lives, (ii) help them to live longer, and (iii) to do so at a reasonable cost. These are our true endpoints: health status, survival, and cost. It is thus entirely consistent with this point of view that these are the fundamental concepts that can be united in a formal cost–utility ...
Weintraub, William S +2 more
openaire +4 more sources
Incorporating Covariates into Measures of Surrogate Paradox Risk
Stats, 2023 Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani +3 more
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Selection of Endpoints for Clinical Studies of Ophthalmic Drugs
Регуляторные исследования и экспертиза лекарственных средств, 2021 Until now, there have been no effective treatments for some ophthalmic diseases that have high social significance. Development of therapeutic approaches to such diseases may be complicated due to challenges in diagnosis and selection of clinical trial ...
M. O. Komarova
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