Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more [PDF]
BMJ OncologyClinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tumour growth, tumour shrinkage, blood results, etc ...
Vinay Prasad +4 more
doaj +2 more sources
Correlation between surrogate endpoints and overall survival in unresectable hepatocellular carcinoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis [PDF]
Scientific ReportsThis study aimed to assess the therapeutic effect of immune checkpoint inhibitors (ICIs) in patients with unresectable hepatocellular carcinoma (uHCC) and investigate the correlation between surrogate endpoints and overall survival (OS).
Litao Huang +3 more
doaj +2 more sources
Surrogate endpoints for neonatal outcome: A rapid review [PDF]
Health Science ReportsShiraz El Adam +3 more
doaj +2 more sources
Кардиоваскулярная терапия и профилактика, 2022 The importance of high-quality randomized controlled trials cannot be overemphasized. Each such study attempts to answer a specific clinical question. To do this, it is necessary to determine in advance the indicator of achievement of a specific result ...
A. R. Navasardyan, S. Yu. Martsevich
doaj +1 more source
Frequently asked questions on surrogate endpoints in oncology-opportunities, pitfalls, and the way forward [PDF]
EClinicalMedicineAbhenil Mittal +2 more
exaly +2 more sources
The perils of surrogate endpoints [PDF]
European Heart Journal, 2015 Our goals in medicine are (i) to improve the quality of patients' lives, (ii) help them to live longer, and (iii) to do so at a reasonable cost. These are our true endpoints: health status, survival, and cost. It is thus entirely consistent with this point of view that these are the fundamental concepts that can be united in a formal cost–utility ...
Weintraub, William S +2 more
openaire +5 more sources
Patient Centered Outcomes in Periodontal Treatment-An Evidenced Based Approach [PDF]
Journal of Clinical and Diagnostic Research, 2017 Transformation of research into clinical practice is the most challenging step in evidence based dental practice. Designing the most reliable research with applicable endpoint evaluation is very important as it can lead to successful research outcomes ...
Ekta Bharatbhai Shah +3 more
doaj +1 more source
Reply to Commentary by Cummings (2022): Surrogate endpoints extend beyond biomarkers [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Anthony Muchai Manyara +2 more
doaj +2 more sources
Incorporating Covariates into Measures of Surrogate Paradox Risk
Stats, 2023 Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani +3 more
doaj +1 more source
Selection of Endpoints for Clinical Studies of Ophthalmic Drugs
Регуляторные исследования и экспертиза лекарственных средств, 2021 Until now, there have been no effective treatments for some ophthalmic diseases that have high social significance. Development of therapeutic approaches to such diseases may be complicated due to challenges in diagnosis and selection of clinical trial ...
M. O. Komarova
doaj +1 more source