Results 231 to 240 of about 79,600 (335)

Surrogate endpoints for new colorectal cancer drugs [PDF]

, 2000
Meta-Analysis Group in Cancer
openalex   +1 more source

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

A hierarchical Bayesian approach for the evaluation of surrogate endpoints in multiple randomized clinical trials

, 2003
Ziv Shkedy, Ferran Torres, Tomasz Burzykowski, Geert Molenberghs   +3 more
openalex   +1 more source

High‐Concentration Mesogen‐Assisted Exfoliation of Low‐Dimensional Nanomaterials for Achieving Ultralow‐Temperature Actuations of Liquid Crystal Elastomers

Advanced Functional Materials, EarlyView.
Most matter is nominally frozen in the polar regions or space, and liquid crystal materials are no exception. Consequently, soft actuators, including liquid crystal elastomers (LCEs), are inoperative under such extreme cold in response to stimuli, as their motion relies on mechanical deformation.
Hyeonseong Kim, Yeon Gyeong Ha, Dong‐Gue Kang, Chinedum O. Osuji, Dae Seok Kim, Changyeon Lee   +5 more
wiley   +1 more source

Considerations for using potential surrogate endpoints in cancer screening trials. [PDF]

Lancet Oncol
Webb AB, Berg CD, Castle PE, Crosby D, Etzioni R, Kessler LG, Menon U, Parmar M, Steele RJC, Sasieni PD.   +9 more
europepmc   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Improving the clinical meaning of surrogate endpoints: An empirical assessment of clinical progression in phase III oncology trials. [PDF]

Int J Cancer
Sherry AD, Lin TA, McCaw ZR, Beck EJ, Kouzy R, Abi Jaoude J, Passy AH, Miller AM, Kupferman GS, Fuller CD, Thomas CR, Koay EJ, Tang C, Msaouel P, Ludmir EB.   +14 more
europepmc   +1 more source

Cryo‐EM of Rationally Designed Photosystem I Nanoassembly on Graphene Validates Orientation‐Driven Enhancement of Photocatalytic Performance

Advanced Functional Materials, EarlyView.
The first cryo‐EM visualization and quantification of oriented Photosystem I (PSI) on single‐layer graphene is reported. Domain‐specific covalent anchoring of PSI, with the reducing side of the biophotocatalyst toward graphene, promotes three‐fold higher anodic photocurrent generation compared to a randomly physisorbed counterpart. This approach allows
Miriam Izzo, Margot Jacquet, Tomasz Góral, Marcin Strawski, Takayuki Fujiwara, Shin‐ya Miyagishima, Joanna Kargul   +6 more
wiley   +1 more source

Optimal candidates and surrogate endpoints for HAIC versus Sorafenib in hepatocellular carcinoma: an updated systematic review and meta-analysis. [PDF]

Int J Surg
Si T, Shao Q, Jassem W, Ma Y, Heaton N.
europepmc   +1 more source

Evaluation of six months sputum culture conversion as a surrogate endpoint in a multidrug resistant-tuberculosis trial

, 2018
Paul Meyvisch, Chrispin Kambili, Koen Andries, Nacer Lounis, Myriam Theeuwes, Brian Dannemann, An Vandebosch, Wim Van der Elst, Geert Molenberghs, Ariel Alonso   +9 more
openalex   +2 more sources