Results 81 to 90 of about 79,600 (335)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A review of evidence supporting amyloid beta reduction as a surrogate endpoint in Alzheimer’s disease

The Journal of Prevention of Alzheimer's Disease
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disease driven by pathological depositions of proteins that accumulate over decades. Compelling genetic and neurobiological evidence suggests that amyloid accumulation in the brain initiates ...
Tianle Chen, R. Matthew Hutchison, Carrie Rubel, Jennifer Murphy, Jing Xie, John O’Gorman, Gersham Dent, Geert Molenberghs, Maria Pia Sormani, Suzanne Hendrix, Oskar Hansson, Paul Aisen, Samantha Budd Haeberlein, Ying Tian   +13 more
doaj   +1 more source

Estimating Treatment Effects using Multiple Surrogates: The Role of the Surrogate Score and the Surrogate Index

, 2020
Estimating the long-term effects of treatments is of interest in many fields. A common challenge in estimating such treatment effects is that long-term outcomes are unobserved in the time frame needed to make policy decisions.
Athey, Susan, Chetty, Raj, Imbens, Guido, Kang, Hyunseung   +3 more
core  

A multistate model for early decision making in oncology

, 2018
The development of oncology drugs progresses through multiple phases, where after each phase a decision is made about whether to move a molecule forward.
Beyer, Ulrich, Burger, Hans Ulrich, Dejardin, David, Meller, Matthias, Rufibach, Kaspar   +4 more
core   +1 more source

Oral contraceptives combined with interferon β in multiple sclerosis [PDF]

, 2015
Objective: To test the effect of oral contraceptives (OCs) in combination with interferon b (IFN-b) on disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).
Barletta, Valeria T., De Angelis, Floriana, De Giglio, Laura, Gallo, Valentina, Marinelli, Fabiana, Marini, Stefano, Pagano, Veronica A., Pantano, Patrizia, Piattella, Maria C., Pozzilli, Carlo, Tomassini, Valentina   +10 more
core   +3 more sources

2408TiP DISCUS: A randomised phase II study of 3 vs 6 cycles of chemotherapy followed by maintenance avelumab in advanced urothelial cancer - Wearable devices and circulating biomarkers assessing quality of life and surrogate efficacy endpoints [PDF]

, 2023
Francesca Jackson‐Spence, Álvaro Pinto Marín, Javier Puente, Javier Molina‐Cerrillo, Syed A. Hussain, Charlotte Ackerman, Nana Osei Bonsu, J. Kelly, Yohann Loriot, Tom Powles, Enrique Grande Pulido   +10 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
A Barbato, A Chetta, AL James, C Owens, C Ward, D Payne, DG Altman, DN Payne, HR Roberts, HW Chu, J de Blic, K Kasahara, KO McKay, P Jeffery, P Sullivan, PA de Jong, PG Woodruff, PK Jeffery, S Saglani, SA Little, SM Stick, TR Bai, V Marchac, Y Nakano   +23 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Discussion of `Causation and Graphical Models? [PDF]

, 2003
C
Vansteelandt, Stijn
core   +1 more source