Results 11 to 20 of about 145,000 (257)

Surrogate Markers of Tumoral Angiogenesis [PDF]

The International Journal of Biological Markers, 2000
Background Angiogenesis is a prerequisite for tumor growth and metastasis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells as a result of vascular endothelial growth factor (VEGF) stimulation.
G.J. Byrne, N.J. Bundred
doaj   +4 more sources

Surrogate Markers for Cardiovascular Disease [PDF]

Circulation, 2004
Pignoli et al1 validated the concept that intima-media thickness (IMT), as measured by B-mode ultrasound and applied either in vitro or in situ at the time of autopsy, reflected direct measurements of aortic and/or carotid specimens. Values obtained by ultrasound at autopsy and by direct measurement were similar to those obtained from living subjects ...
Dahlöf, B. (Björn), Diez-Martinez, J. (Javier), Mancini, G.B.J. (G. B. John)   +2 more
openaire   +6 more sources

The impact of analgesic on EMG and other biosignals in a postoperative setting

Frontiers in Medicine, 2023
BackgroundIn the clinical context, the assessment of pain in patients with inadequate communication skills is standardly performed externally by trained medical staff. Automated pain recognition (APR) could make a significant contribution here.
Sascha Gruss, Matthias Schmid, Steffen Walter, Benedikt Schick, Lena Holler, Eberhard Barth   +5 more
doaj   +1 more source

Quantitation of HIV-1 RNA Viral Load Using NASBA Methodology and Comparison with other Surrogate Markers for Disease Progression [PDF]

Memorias do Instituto Oswaldo Cruz, 1998
In this study, HIV-1 viral load quantitation determined by Nucleic Acid Sequence Based Amplification (NASBA) was compared with other surrogate disease progression markers (antigen p24, CD4/CD8 cell counts and b-2 microglobulin) in 540 patients followed ...
Roberta Sitnik, João Renato Rebello Pinho   +1 more
doaj   +1 more source

Mid Upper Arm Circumference as the Best Surrogate Marker for Identification of Low Birth Weight in Newborns within the First 24 Hours of Life- A Cross-sectional Study

Indian Journal of Neonatal Medicine and Research, 2023
Introduction: Birth weight is a very important determinant factor regarding perinatal morbidity and mortality. However, in developing countries like India weighing facility may not be available in rural areas where an alternative anthropometric parameter
Jayashri Chandrakant Sawale, Leena Ajay Dhande, Pooja Bhimashankar Nagrale   +2 more
doaj   +1 more source

Incorporating Covariates into Measures of Surrogate Paradox Risk

Stats, 2023
Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani, Jeremy M. G. Taylor, Niko Kaciroti, Michael R. Elliott   +3 more
doaj   +1 more source

Robust evaluation of longitudinal surrogate markers with censored data [PDF]

Journal of the Royal Statistical Society Series B: Statistical Methodology
Layla Parast, Denis Agniel
exaly   +2 more sources

Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study

BMC Medicine, 2018
Background The U.S. Food and Drug Administration (FDA) often approves new drugs based on trials that use surrogate markers for endpoints, which involve certain trade-offs and may risk making erroneous inferences about the medical product’s actual ...
Joshua D. Wallach, Oriana Ciani, Alison M. Pease, Gregg S. Gonsalves, Harlan M. Krumholz, Rod S. Taylor, Joseph S. Ross   +6 more
doaj   +1 more source

Can earlier biomarker measurements explain a treatment effect on diabetes incidence? A robust comparison of five surrogate markers

BMJ Open Diabetes Research & Care, 2023
Introduction We measured and compared five individual surrogate markers—change from baseline to 1 year after randomization in hemoglobin A1c (HbA1c), fasting glucose, 2-hour postchallenge glucose, triglyceride–glucose index (TyG) index, and homeostatic ...
Lu Tian, Tianxi Cai, Latha P Palaniappan, Layla Parast   +3 more
doaj   +1 more source

Introduction to Surrogate Markers [PDF]

Circulation, 2004
The clinical complications of atherosclerosis and atherothrombotic disease represent the major causes of morbidity and mortality in the United States and worldwide. The disorders that shorten life expectancy include myocardial infarction and ischemia, heart failure, stroke, renal failure, peripheral vascular disease, sudden death, and dementia, in all ...
openaire   +2 more sources