Results 91 to 100 of about 22,296,575 (338)

A new AI-surrogate model for dynamics analysis of a magnetorheological damper in the semi-active seat suspension

Smart materials and structures (Print), 2020
This paper aims to develop a surrogate model for dynamics analysis of a magnetorheological damper (MRD) in the semi-active seat suspension system. An improved fruit fly optimization algorithm (IFOA) which enhances the global search capability of the ...
Xinhua Liu, Ningning Wang, Kun Wang, Shumei Chen, Shuaishuai Sun, Zhixiong Li, Weihua Li   +6 more
semanticscholar   +1 more source

An adaptive sampling method for global sensitivity analysis based on least-squares support vector regression [PDF]

, 2018
In the field of engineering, surrogate models are commonly used for approximating the behavior of a physical phenomenon in order to reduce the computational costs.
Bourinet, Jean-Marc, Lahmer, Tom (Prof.), Steiner, Maria (M.Sc.)   +2 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Online learning supported surrogate-based flowsheet model maintenance

Digital Chemical Engineering
Surrogate-based flowsheet model calibration is a critical extension of using flowsheet models in Digital Twin (DT) systems. However, maintaining accurate surrogates over time is increasingly challenging, especially when models are deployed in real-time ...
Balázs Palotai, Gábor Kis, Tibor Chován, Ágnes Bárkányi   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Surrogate Model Assisted Design of CSRR Structure using Genetic Algorithm for Microstrip Antenna Application [PDF]

Radioengineering, 2020
Soft-computational approaches have enabled quicker and more efficient means for antenna design. In the present work, a genetic algorithm (GA) based method is reported for the design of complementary split ring resonator (CSRR) structures for antenna ...
K. Sarmah, S. Goswami, S. Baruah
doaj  

Surrogate Modeling: Review and Opportunities for Expert Knowledge Integration

Procedia Computer Science
Digital Twins (DTs), essential for digitalization and Industry 4.0, demand high-fidelity yet computationally efficient models for real-time replication of physical systems. However, simulating continuous dynamical systems, often stiff and highly granular, poses significant computational challenges.
Šturek, Dušan, Lazarova-Molnar, Sanja
openaire   +3 more sources

A surrogate function for one-dimensional phylogenetic likelihoods

, 2017
Phylogenetics has seen an steady increase in substitution model complexity, which requires increasing amounts of computational power to compute likelihoods.
Brian C Claywell, Connor O McCoy, Frederick A Matsen IV, Mathieu Fourment, Vu Dinh   +4 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source