Results 91 to 100 of about 557,108 (293)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Adaptive Surrogate-Assisted Particle Swarm Optimization Algorithm Combining Effectively Global and Local Surrogate Models and Its Application

Applied Sciences
Numerous surrogate-assisted evolutionary algorithms have been proposed for expensive optimization problems. However, each surrogate model has its own characteristics and different applicable situations, which caused a serious challenge for model ...
Shaochun Qu, Fuguang Liu, Zijian Cao
doaj   +1 more source

Variable-fidelity optimization of microwave filters using co-kriging and trust regions [PDF]

, 2012
In this paper, a variable-fidelity optimization methodology for simulation-driven design optimization of filters is presented. We exploit electromagnetic (EM) simulations of different accuracy.
Couckuyt, Ivo, Dhaene, Tom, Koziel, Slawomir   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A high-fidelity surrogate model for the ion temperature gradient (ITG) instability using a small expensive simulation dataset

Nuclear Fusion
One of the main challenges in building high-fidelity surrogate models of tokamak turbulence is the substantial demand for high-quality data. Typically, producing high-quality data involves simulating complex physical processes, which requires extensive ...
Chenguang Wan, Youngwoo Cho, Zhisong Qu, Yann Camenen, Robin Varennes, Kyungtak Lim, Kunpeng Li, Jiangang Li, Yanlong Li, Xavier Garbet   +9 more
doaj   +1 more source

Radiation shielding optimization based on dynamic radial basis surrogate model of particle flight

He jishu
BackgroundRadiation shielding is crucial for ensuring the environmental safety of personnel and nuclear facilities in the nuclear industry. As it usually consumes a long time in single simulation calculation, the optimization design of radiation ...
GAO Shuai, GUAN Xingyin, LU Yi, YE Yang, YUAN Yuan, HAO Shuai, HU Qihang, ZHANG Yong   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Considerations of Accuracy and Uncertainty with Kriging Surrogate Models in Single-Objective Electromagnetic Design Optimization

, 2007
The high computational cost of evaluating objective functions in electromagnetic optimal design problems necessitates the use of cost-effective techniques.
Hawe, G., Sykulski, J.K.
core