Results 131 to 140 of about 14,186,820 (252)
A surrogate model for capturing wave power farm dynamics using spatial-temporal attention. [PDF]
Sci RepStavropoulou C, Faedo N, Göteman M.
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
MLP-residual surrogate model for aerodynamic prediction in projectile external flows. [PDF]
Sci ProgXin S, Hao Y, Zhang J.
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Reliability Optimization of the Honeycomb Sandwich Structure Based on A Neural Network Surrogate Model. [PDF]
Materials (Basel), 2023 Wei Z, Zhou C, Zhang F, Zhou C.
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Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Multi-objective optimization design of linear oscillating actuator based on hybrid surrogate model. [PDF]
Sci RepYu M, Lin J, Zhang Y.
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A novel adaptive-weight ensemble surrogate model base on distance and mixture error. [PDF]
PLoS One, 2023 Lu J, Fang Y, Han W.
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A multiscale topology optimization design framework with data driven surrogate model. [PDF]
Sci RepZhou H, Zhou C.
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source