Results 141 to 150 of about 247,811 (265)

A multiscale topology optimization design framework with data driven surrogate model. [PDF]

Sci Rep
Zhou H, Zhou C.
europepmc   +1 more source

Research on surrogate model of dam numerical simulation with multiple outputs based on adaptive sampling. [PDF]

Sci Rep, 2023
Liang J, Li Z, Pan L, Khailah EY, Sun L, Lu W.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Design optimization of battery enclosures under nonlinear impact loading using a K-Kriging hybrid surrogate model. [PDF]

Sci Rep
Li H, Chen F, Wan C.
europepmc   +1 more source

Embodied Energy Optimization of Prestressed Concrete Road Flyovers by a Two-Phase Kriging Surrogate Model. [PDF]

Materials (Basel), 2023
Yepes-Bellver L, Brun-Izquierdo A, Alcalá J, Yepes V.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Determination of the parameters of a material constitutive relation using the surrogate model along with dynamic indentation test. [PDF]

Sci Rep
Majzoobi GH, Pourolajal S.
europepmc   +1 more source

Smooth Things Come in Threes: A Diabatic Surrogate Model for Conical Intersection Optimization. [PDF]

J Chem Theory Comput, 2023
Fdez Galván I, Lindh R.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A General Surrogate Model for CO₂ Flooding Dynamic Prediction Based on Dimensionless Features and Implicit Time. [PDF]

ACS Omega
Li C, Wang X, Yu W, Zhou P.
europepmc   +1 more source