FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
A multiscale topology optimization design framework with data driven surrogate model. [PDF]
Sci RepZhou H, Zhou C.
europepmc +1 more source
The Application of a Topology Optimization Algorithm Based on the Kriging Surrogate Model in the Mirror Design and Optimization of an Aerial Camera. [PDF]
Sensors (Basel), 2023 Zhao Y, Li L.
europepmc +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Determination of the parameters of a material constitutive relation using the surrogate model along with dynamic indentation test. [PDF]
Sci RepMajzoobi GH, Pourolajal S.
europepmc +1 more source
ANN based surrogate model for key Physico-chemical effects of cavitation. [PDF]
Ultrason Sonochem, 2023 Ranade NV, Ranade VV.
europepmc +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
A General Surrogate Model for CO<sub>2</sub> Flooding Dynamic Prediction Based on Dimensionless Features and Implicit Time. [PDF]
ACS OmegaLi C, Wang X, Yu W, Zhou P.
europepmc +1 more source
A data-driven reduced-order surrogate model for entire elastoplastic simulations applied to representative volume elements. [PDF]
Sci Rep, 2023 Vijayaraghavan S +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source