Results 81 to 90 of about 557,108 (293)

Surrogate Modeling: Review and Opportunities for Expert Knowledge Integration

open access: yesProcedia Computer Science
Digital Twins (DTs), essential for digitalization and Industry 4.0, demand high-fidelity yet computationally efficient models for real-time replication of physical systems. However, simulating continuous dynamical systems, often stiff and highly granular, poses significant computational challenges.
Šturek, Dušan, Lazarova-Molnar, Sanja
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Surrogate Model Assisted Design of CSRR Structure using Genetic Algorithm for Microstrip Antenna Application [PDF]

open access: yesRadioengineering, 2020
Soft-computational approaches have enabled quicker and more efficient means for antenna design. In the present work, a genetic algorithm (GA) based method is reported for the design of complementary split ring resonator (CSRR) structures for antenna ...
K. Sarmah, S. Goswami, S. Baruah
doaj  

KL-based Control of the Learning Schedule for Surrogate Black-Box Optimization [PDF]

open access: yes, 2013
This paper investigates the control of an ML component within the Covariance Matrix Adaptation Evolution Strategy (CMA-ES) devoted to black-box optimization.
Loshchilov, Ilya   +2 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Active learning based surrogate ensemble assisted multi-objective optimization framework for reservoir water-flooding optimization

open access: yesJournal of Petroleum Exploration and Production Technology
Surrogate-assisted management of water-flooding, as a reservoir production optimization strategy, dynamically adjusts development schemes at each production step, leading to improved economic benefits and enhanced recovery.
Lian Wang   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Simulation of the Oxidation and Combustion of Mixed Diesel-Biodiesel Fuel

open access: yesMATEC Web of Conferences, 2018
A comparative simulation-based research has been set up to obtain valid kinetic models of the oxidation and combustion of biodiesel surrogate and diesel surrogate, as well as mixed diesel-biodiesel surrogates which is used to predict their ignition delay
Muharam Yuswan   +2 more
doaj   +1 more source

Rapidly Tuning the PID Controller Based on the Regional Surrogate Model Technique in the UAV Formation

open access: yesEntropy, 2020
The leader–follower structure is widely used in unmanned aerial vehicle formation. This paper adopts the proportional-integral-derivative (PID) and the linear quadratic regulator controllers to construct the leader–follower formation.
Binglin Wang   +4 more
doaj   +1 more source

Surrogate Residuals for Discrete Choice Models

open access: yesJournal of Computational and Graphical Statistics, 2020
Discrete choice models (DCMs) are a class of models for modeling response variables that take values from a set of alternatives. Examples include logistic regression, probit regression, and multinomial logistic regression. These models are also referred together as generalized linear models. Although there exist methods for the goodness of fit of DCMs,
Chao, Cheng, Rui, Wang, Heping, Zhang
openaire   +3 more sources

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