Results 221 to 230 of about 24,324,331 (382)

Surrogate modeling for time-dependent reliability analysis of robotic manipulator trajectories. [PDF]

PLoS One
Ayoob K, Elahi H, Zafar T, Hamza A, Wang Z.   +4 more
europepmc   +1 more source

Avoiding overfitting in surrogate modeling: an alternative approach [PDF]

, 2011
Couckuyt, Ivo, Dhaene, Tom, Gorissen, Dirk, Knockaert, Luc, Nguyen, Huu Minh, Saeys, Yvan   +5 more
core  

Reliable low-cost co-kriging modeling of microwave devices [PDF]

, 2012
Couckuyt, Ivo, Dhaene, Tom, Koziel, Slawomir   +2 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Hybrid Multimodal Surrogate Modeling and Uncertainty-Aware Co-Design for L-PBF Ti-6Al-4V with Nanomaterials-Informed Morphology Proxies. [PDF]

Nanomaterials (Basel)
Hossain RB, Pan X, Chang G, Su X, Tao Y, Han X.   +5 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Optimization of the grid-stiffened structure via PSO-LSSVR surrogate modeling and sensitivity analysis. [PDF]

Sci Rep
Gai J, Jian Y, Deng Q, Wang J, Zheng M, Yang Y.   +5 more
europepmc   +1 more source

Constructing classifiers of expensive simulation-based data by sequential experimental design [PDF]

, 2015
Couckuyt, Ivo, Deschrijver, Dirk, Dhaene, Tom, van der Herten, Joachim   +3 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

3D Urban Outdoor WiFi 7 Network Planning and Analysis Using Ray-Tracing and Machine Learning: Transformer-Based Surrogate Modeling for High-Resolution Digital Twin. [PDF]

Sensors (Basel)
Trînc EC, Ancuți C, Vesa A, Simu C, Niță VA, Stolojescu-Crişan C.   +5 more
europepmc   +1 more source