Results 201 to 210 of about 2,763,762 (257)

Surrogate modeling of Cellular-Potts agent-based models as a segmentation task using the U-Net neural network architecture. [PDF]

PLoS Comput Biol
Comlekoglu T, Toledo-Marín JQ, Comlekoglu T, DeSimone DW, Peirce SM, Fox G, Glazier JA.   +6 more
europepmc   +1 more source

Surfing on Fitness Landscapes: A Boost on Optimization by Fourier Surrogate Modeling. [PDF]

Entropy (Basel), 2020
Manzoni L, Papetti DM, Cazzaniga P, Spolaor S, Mauri G, Besozzi D, Nobile MS.   +6 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Optimal control of agent-based models via surrogate modeling. [PDF]

PLoS Comput Biol
Fonseca LL, Böttcher L, Mehrad B, Laubenbacher RC.   +3 more
europepmc   +1 more source

ASAMS: An Adaptive Sequential Sampling and Automatic Model Selection for Artificial Intelligence Surrogate Modeling. [PDF]

Sensors (Basel), 2020
Duchanoy CA, Calvo H, Moreno-Armendáriz MA.   +2 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Surrogate modeling of passive microwave circuits using recurrent neural networks and domain confinement. [PDF]

Sci Rep
Sahu KC, Koziel S, Pietrenko-Dabrowska A.   +2 more
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Nominal elastic modulus assessment in 3D-printed components under varying printing parameters using Bayesian methods and random forest surrogate modeling. [PDF]

PLoS One
Zhang J, Lu L, Feng P, Zhu T.
europepmc   +1 more source