Results 61 to 70 of about 186,324 (294)

Large scale variable fidelity surrogate modeling [PDF]

Annals of Mathematics and Artificial Intelligence, 2017
Engineers widely use Gaussian process regression framework to construct surrogate models aimed to replace computationally expensive physical models while exploring design space. Thanks to Gaussian process properties we can use both samples generated by a high fidelity function (an expensive and accurate representation of a physical phenomenon) and a ...
A. Zaytsev, E. Burnaev
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Non-Deterministic Methods and Surrogates in the Design of Rockfill Dams

Applied Sciences, 2021
The parameters of the constitutive models used in the design of rockfill dams are associated with a high degree of uncertainty. This occurs because rockfill dams are comprised of numerous zones, each with different soil materials, and it is not feasible ...
Rajeev Das, Azzedine Soulaimani
doaj   +1 more source

Fuzzy local linear approximation-based sequential design [PDF]

, 2014
When approximating complex high-fidelity black box simulators with surrogate models, the experimental design is often created sequentially. LOLA-Voronoi, a powerful state of the art method for sequential design combines an Exploitation and Exploration ...
Deschrijver, Dirk, Dhaene, Tom, van der Herten, Joachim   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Rapid Design and Fabrication of Body Conformable Surfaces with Kirigami Cutting and Machine Learning

Advanced Science
By integrating the principles of kirigami cutting and data‐driven modeling, this study aims to develop a personalized, rapid, and low‐cost design and fabrication pipeline for creating body‐conformable surfaces around the knee joint.
Jyotshna Bali, Jinyang Li, Jie chen, Suyi Li   +3 more
doaj   +1 more source

A surrogate modeling and adaptive sampling toolbox for computer based design [PDF]

, 2010
An exceedingly large number of scientific and engineering fields are confronted with the need for computer simulations to study complex, real world phenomena or solve challenging design problems.
Couckuyt, Ivo, Crombecq, Karel, Demeester, Piet, Dhaene, Tom, Gorissen, Dirk   +4 more
core  

Convergence of Weak-SINDy Surrogate Models

SIAM Journal on Applied Dynamical Systems
In this paper, we give an in-depth error analysis for surrogate models generated by a variant of the Sparse Identification of Nonlinear Dynamics (SINDy) method. We start with an overview of a variety of non-linear system identification techniques, namely, SINDy, weak-SINDy, and the occupation kernel method.
Benjamin P. Russo, M. Paul Laiu
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source