Results 201 to 210 of about 223,298 (311)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Single-Objective Surrogate Models for Continuous Metaheuristics: An Overview

This paper presents a comprehensive overview of single-objective surrogate models for continuous metaheuristics, addressing computationally expensive optimization problems.
Jarosław Arabas, Konrad Krawczyk
core   +1 more source

Surrogate Models for CO₂ Utilization Pathways: Accelerating Industrial Park Design and Enterprise-Wide Optimization. [PDF]

ACS Omega
Faadil M, Alhajeri MS, Almansoori A, Elkamel A.   +3 more
europepmc   +1 more source

Framework for the Development of Affective and Smart Manufacturing Systems Using Sensorised Surrogate Models. [PDF]

Sensors (Basel), 2021
Ávila-Gutiérrez MJ, Aguayo-González F, Lama-Ruiz JR.   +2 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Integrating Machine Learning with Hybrid and Surrogate Models to Accelerate Multiscale Modeling of Acute Respiratory Infections. [PDF]

Viruses
Korzin A, Koshkareva M, Leonenko V.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Development of machine learning surrogate models for slope stability prediction using AI techniques: a case study of the Meizhou landslide. [PDF]

Sci Rep
Khan MI, Fei J, Chen X, Hamza M.
europepmc   +1 more source

Surrogate models based on machine learning methods for parameter estimation of left ventricular myocardium. [PDF]

R Soc Open Sci, 2021
Cai L, Ren L, Wang Y, Xie W, Zhu G, Gao H.   +5 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source