Results 181 to 190 of about 223,298 (311)

Adsorption kinetics of 20 glucocorticoids at environmentally relevant concentrations in wastewater by powdered activated carbons and development of surrogate models. [PDF]

J Water Process Eng, 2022
Zhang A, Luo Y, Jia A, Park M, Daniels KD, Nie X, Wu S, Snyder SA.   +7 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Guaranteed prediction sets for functional surrogate models

International audienceWe propose a method for obtaining statistically guaranteed prediction sets for functional machine learning methods: surrogate models which map between function spaces, motivated by the need to build reliable PDE emulators.
Gopakumar, Vignesh, Destercke, Sébastien, Rousseau, Sylvain, Gray, Ander   +3 more
core   +1 more source

Dose-response functions and surrogate models for exploring social contagion in the Copenhagen Networks Study. [PDF]

Eur Phys J Spec Top, 2021
Donges JF, Lochner JH, Kitzmann NH, Heitzig J, Lehmann S, Wiedermann M, Vollmer J.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Surrogate Modelling Using Phantom-Space Design of Experiments and Adaptive Regression

In many industrial design applications, cutting down the cost of natural experiments or complex simulations involves use of so-called surrogate models that mimic the behaviour of the original system as closely as possible while being much cheaper to ...
Jēkabsons, Gints, Lavendels, Jurijs, Lagzdiņš, Andis   +2 more
core  

Surrogate models provide new insights on metrics based on blood flow for the assessment of left ventricular function. [PDF]

Sci Rep, 2022
Collia D, Libero G, Pedrizzetti G, Ciriello V.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Models for Surrogative Stimulation

Erkenntnis
Abstract Occasionally, in science, models are used to stimulate other systems rather than to perform surrogative reasoning. More specifically, in what is called surrogative stimulation, a model is used to stimulate a focal system in order to learn how it would respond to the system represented by the model.
openaire   +1 more source

Feature Engineering for Surrogate Models of Consolidation Degree in Additive Manufacturing. [PDF]

Materials (Basel), 2021
Roy M, Wodo O.
europepmc   +1 more source