Results 171 to 180 of about 223,298 (311)

Informative censoring in piecewise exponential survival models

open access: yes
There are often reasons to suppose that there is dependence between the time to event and time to censoring, or informative censoring, for survival data, particularly when considering medical data.
Collett, David   +3 more
core  

Neural architecture search using network embedding and generative adversarial networks

open access: yesScientific Reports
Surrogate models are used by recently proposed algorithms as a means of forecasting neural architecture performance. Rather than training the network from scratch, which speeds up evaluation of performance in the search for neural architecture.
Morteza Yousefi   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A Procedure for Surrogate Modelling Using Space-Filling Design of Experiments and Adaptive Regression

open access: yes
In many industrial applications, to cut down either the cost of natural experiments or the computational cost of complex, high fidelity scientific and engineering simulations, they are often substituted with regression models (in this context also ...
Jēkabsons, Gints   +2 more
core  

Multiobjective optimization using surrogates

open access: yes, 2006
Until recently, optimization was regarded as a discipline of rather theoretical interest, with limited real-life applicability due to the comutational or experimental expense involved.
Keane, A.J., Voutchkov, I.
core  

Vapor compression system data-driven surrogate models for aircraft Environmental Control Systems

open access: yes
Commercial aircraft manufacturers are actively working to develop more efficient Environmental Control Systems (ECS) in line with the More Electric Aircraft (MEA) concept.
Oliet Casasayas, Carles   +8 more
core   +1 more source

Efficient Ventricular Parameter Estimation Using AI-Surrogate Models. [PDF]

open access: yesFront Physiol, 2021
Maso Talou GD   +2 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Self-learning surrogate models in superstructure optimization

open access: yes
In this contribution, we propose an algorithm for replacing non-linear process simulation integrated in multi-level optimization of an energy system superstructure with surrogate models. With our approach, we demonstrate that surrogate models are a valid
Kantor, Ivan Daniel   +3 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

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