Results 161 to 170 of about 223,298 (311)

A Heuristic Approach for Surrogate Modelling of Electro-Technical Systems

The optimization of designs of electro-technical systems often is based on expensive calculations (i.e., simulation models). To cut down the cost, surrogate models are constructed from and then used in place of simulations.
Jēkabsons, Gints, Lavendels, Jurijs
core  

Uncertainty propagation in pore water chemical composition calculation using surrogate models. [PDF]

Sci Rep, 2022
Sochala P, Chiaberge C, Claret F, Tournassat C.   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Groundwater Pollution Source Identification via an Integrated Surrogate Model and Multiobjective Heuristic Optimization Algorithms

Water Resources Research
Simulation‐optimization methods are commonly used in groundwater pollution source identification. Traditional simulation‐optimization methods require multiple calls to the numerical model, which leads to a considerable computational burden.
Shengjie Hu, Zuorong Xu, Rui Zuo, Jingchao Liu   +3 more
doaj   +1 more source

Physics-Based AI-Driven Surrogate Modeling for Structural Displacement Prediction in Mechanical Systems With Limited Sensor Data

IEEE Access
This study introduces a machine learning (ML)-based surrogate model for finite element analysis, designed to predict structural strain distributions using a minimal number of strategically placed virtual sensors.
Ali Hashemi, Javad Beheshti, Mahdieh Mohammadi   +2 more
doaj   +1 more source

Adaptive Weighted Strategy Based Integrated Surrogate Models for Multiobjective Evolutionary Algorithm. [PDF]

Comput Intell Neurosci, 2022
Bao K, Fang W, Ding Y.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on Surrogate Model of Dam Structural Behavior for Multi‐Output Problem

Engineering Reports
The establishment efficiency of the surrogate model is often affected by the multi‐output problem during the establishment process. It is an urgent issue to solve how to establish a multi‐output joint surrogate model more quickly while ensuring a certain
Yuan Qiao, Liang Jiaming, Li Zhanchao, Ebrahim Yahya Khailah   +3 more
doaj   +1 more source

Multi-objective robust optimization using adaptive surrogate models for problems with mixed continuous-categorical parameters. [PDF]

Struct Multidiscipl Optim, 2022
Moustapha M, Galimshina A, Habert G, Sudret B.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source