Results 161 to 170 of about 217,450 (265)

Using Adaptive Surrogate Models to Accelerate Multi-Objective Design Optimization of MEMS. [PDF]

Micromachines (Basel)
Nazari A, Aghajani A, Buhr P, Park B, Wang Y, Shafai C.   +5 more
europepmc   +1 more source

Surrogate models based on machine learning methods for parameter estimation of left ventricular myocardium. [PDF]

R Soc Open Sci, 2021
Cai L, Ren L, Wang Y, Xie W, Zhu G, Gao H.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Direct Deoxygenation of Phenol over Fe-Based Bimetallic Surfaces Using On-the-Fly Surrogate Models. [PDF]

J Phys Chem C Nanomater Interfaces
Onyango I, Zhu Q.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Efficient black-box attack with surrogate models and multiple universal adversarial perturbations. [PDF]

Sci Rep
Ma T, Zhao H, Tang L, Xue M, Liu J.
europepmc   +1 more source

Using physical property surrogate models to perform accelerated multi-fidelity optimization of force field parameters.

Digit Discov, 2023
Madin OC, Shirts MR.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Parametric Optimization of VLM Panel Discretization Using Bio-Inspired Crayfish and Aquila Algorithms Coupled with Hybrid RSM-Based Ensemble Machine Learning Surrogate Models: A Case Study. [PDF]

Biomimetics (Basel)
Eraslan Y, Şengün E.
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source