Results 141 to 150 of about 223,298 (311)

Surrogate Modelling for High-speed Rotating Flow Fields Based on Multi-fidelity Data Fusion

Journal of Isotopes
High-speed rotating flow fields play a pivotal role in the mechanical systems used for stable heavy isotopes. The high dimensional design space of such complex rotating machinery is characterized by strong nonlinearity and substantial parameter coupling.
Xiaowei XU, Zhiyong GU, Wenjuan WU, Songjie TIAN   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Modeling and the Use of Surrogate Endpoints: Is This a Valid Approach?

Digestive Diseases and Sciences
Abstract Development of novel colorectal cancer (CRC) screening tests is a dynamic field. Decision analytic modeling based on inputs derived from rigorous prospective studies informs CRC screening guidelines. Exploratory modeling may have a place in early phases of test development.
Ladabaum, Uri, van Duuren, Luuk A., Half, Elizabeth E., Levi, Zohar, Silverman, Barbara, Lansdorp-Vogelaar, Iris   +5 more
openaire   +2 more sources

Reducing Tolerance‐Induced Spread on Transmission Error in Planetary Gear Stages Using Monte Carlo Simulations and Surrogate Models Acquired From a Design of Experiments Approach

Wind Energy
Significant variations in tonality levels are frequently observed among nominally identical wind turbine drivetrains, both in industrial test setups and during field operations, posing challenges to compliance with noise emission standards.
Bart De Smet, Jordi Marco I. Jordan, Bart Blockmans, Philip Becht, Nico De Bie, Frank Naets   +5 more
doaj   +1 more source

Fatigue Damage Assessment of Offshore Wind Turbine Foundation Under Coupled Wind–Wave Loading Using Surrogate Modeling

Energies
This study develops an efficient fatigue prediction framework for offshore wind turbine (OWT) monopile foundations under coupled wind–wave conditions using four surrogate models: XGBoost, Random Forest (RF), Support Vector Regression (SVR), and Gaussian ...
Chong Dai, Jinhai Zhao, Rui Sun
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Impact of surrogate model accuracy on performance and model management strategy in surrogate-assisted evolutionary algorithms

Array
Surrogate-assisted evolutionary algorithms (SAEAs) have been proposed to solve expensive optimization problems. Although SAEAs use surrogate models that approximate the evaluations of solutions using machine learning techniques, prior research has not adequately investigated the impact of surrogate model accuracy on search performance and model ...
Yuki Hanawa, Tomohiro Harada, Yukiya Miura   +2 more
openaire   +2 more sources

Heterogeneous Evolution of Surrogate Models

, 2007
Due to the scale and computational complexity of current simulation codes, surrogate models have become indispensable tools for exploring and understanding the design space.
Prof Dirk Roose, Prof Tom Dhaene, Dirk Gorissen, Prof Johan Suykens, Prof Adhemar Bultheel   +4 more
core  

Creation of manufacturing cost estimation surrogate models for application in a cross-organizational design workflow

International audienceEstimating manufacturing cost is a crucial step in evaluating the value of an aircraft design. However, this estimation is often performed only after the design and optimization phases are completed.
Lefebvre, Thierry, van der Laan, Ton, Bartoli, Nathalie   +2 more
core   +1 more source

A machine learning-based comparative analysis of surrogate models for design optimisation in computational fluid dynamics. [PDF]

Heliyon, 2023
Mukhtar A, Yasir ASHM, Nasir MFM.
europepmc   +1 more source