Results 131 to 140 of about 223,298 (311)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Pca & Kriging For Surrogate Models
2nd General Meeting and 2nd Workshop on Smart Energy Carriers in Industry, 2016 Presentation at the 2nd General Meeting and 2nd Workshop on Smart Energy Carriers in ...
Aversano, Gianmarco +2 more
openaire +2 more sources
Full Domain Analysis in Fluid Dynamics
Machine Learning and Knowledge ExtractionNovel techniques in evolutionary optimization, simulation, and machine learning enable a broad analysis of domains like fluid dynamics, in which computation is expensive and flow behavior is complex.
Alexander Hagg +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Conditional Denoising Model as a Physical Surrogate Model
CoRRSurrogate modeling for complex physical systems typically faces a trade-off between data-fitting accuracy and physical consistency. Physics-consistent approaches typically treat physical laws as soft constraints within the loss function, a strategy that frequently fails to guarantee strict adherence to the governing equations, or rely on post ...
José Afonso +3 more
openaire +2 more sources
Surrogate Models for Seismic Response of Structures
, 2023 The seismic risks to a structure or a set of structures in a region are usually determined by generating fragility curves that provide the probability of a building responding in a certain manner for a given level of ground motion intensity.
Nayak, Sanjay
core
Predicting Atomistic Transitions with Transformers
Data Science in ScienceAccurate knowledge of the atomistic transition pathways in materials and material surfaces is crucial for many material science problems. However, conventional simulation techniques used to find these transitions are extremely computationally intensive ...
Henry Tischler +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source