Results 121 to 130 of about 217,450 (265)

Uncertainty propagation in pore water chemical composition calculation using surrogate models. [PDF]

Sci Rep, 2022
Sochala P, Chiaberge C, Claret F, Tournassat C.   +3 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Adaptive Weighted Strategy Based Integrated Surrogate Models for Multiobjective Evolutionary Algorithm. [PDF]

Comput Intell Neurosci, 2022
Bao K, Fang W, Ding Y.
europepmc   +1 more source

Research on Surrogate Model of Dam Structural Behavior for Multi‐Output Problem

Engineering Reports
The establishment efficiency of the surrogate model is often affected by the multi‐output problem during the establishment process. It is an urgent issue to solve how to establish a multi‐output joint surrogate model more quickly while ensuring a certain
Yuan Qiao, Liang Jiaming, Li Zhanchao, Ebrahim Yahya Khailah   +3 more
doaj   +1 more source

Models for Surrogative Stimulation

Erkenntnis
Abstract Occasionally, in science, models are used to stimulate other systems rather than to perform surrogative reasoning. More specifically, in what is called surrogative stimulation, a model is used to stimulate a focal system in order to learn how it would respond to the system represented by the model.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Multi-objective robust optimization using adaptive surrogate models for problems with mixed continuous-categorical parameters. [PDF]

Struct Multidiscipl Optim, 2022
Moustapha M, Galimshina A, Habert G, Sudret B.   +3 more
europepmc   +1 more source

Neural architecture search using network embedding and generative adversarial networks

Scientific Reports
Surrogate models are used by recently proposed algorithms as a means of forecasting neural architecture performance. Rather than training the network from scratch, which speeds up evaluation of performance in the search for neural architecture.
Morteza Yousefi, Vahid Mehrdad, Mohammad Bagher Dowlatshahi   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source