Results 121 to 130 of about 223,298 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Uncertainty quantification of surrogate models using conformal prediction

Machine Learning: Science and Technology
Data-driven surrogate models offer fast, inexpensive approximations to complex numerical and experimental systems but typically lack uncertainty quantification, limiting their reliability in safety-critical applications.
Vignesh Gopakumar, Ander Gray, Joel Oskarsson, Lorenzo Zanisi, Daniel Giles, Matt J Kusner, Stanislas Pamela, Marc Peter Deisenroth   +7 more
doaj   +1 more source

Multi-Objective Optimization of Building Energy Consumption: A Case Study of Temporary Buildings on Construction Sites

Buildings
Building energy consumption management significantly impacts energy efficiency, environmental effects, and economic benefits throughout a building’s life cycle.
Xiaohui Guo, Yuanfeng Wang, Yinshan Liu, Lei Fan, Shaoqin Xue, Chengcheng Shi, Lei Pan, Boqun Zhang, Liping Wang, Xinlei Chang   +9 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Investigating the use of rubber to attenuate the effect of blast load applied to a surrogate lower leg

, 2008
Includes abstract.Includes bibliographical references (leaves 191-197).Landmines are the epitome of the perfect soldier: always ready, never tiring. Landmines also do not choose their victims - it may very well be an armed and protected soldier or an ...
Ungerer, Delmarie
core  

Strategies for balancing exploration and exploitation in electromagnetic optimisation [PDF]

, 2012
The paper focuses on the advantages and drawbacks of different strategies which may be used to assist kriging surrogate modelling with the purpose of selecting multiple design vectors for evaluation when stepping forward in optimisation routines.
Rotaru, M., Sykulski, J. K., Sykulski, J.K., Xiao, Song   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Constructing Surrogate Models for Springback in U-Bending Process

, 2012
In this study, surrogate models are constructed to approximate the behavior of simulation models for springback angles, sidewall curl, and sheet thickness reduction in U-bending process.
Özer, Fırat, Acar, Erdem, Bekar, Deniz, Güler, Mehmet Ali   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Point-Wise Full-Field Physics Neural Mapping Framework via Boundary Geometry Constrained for Large Thermoplastic Deformation

Algorithms
Computation modeling for large thermoplastic deformation of plastic solids is critical for industrial applications like non-invasive assessment of engineering components.
Jue Wang, Xinyi Xu, Changxin Ye, Wei Huangfu   +3 more
doaj   +1 more source