Results 81 to 90 of about 456,731 (293)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Reducing Tolerance‐Induced Spread on Transmission Error in Planetary Gear Stages Using Monte Carlo Simulations and Surrogate Models Acquired From a Design of Experiments Approach

Wind Energy
Significant variations in tonality levels are frequently observed among nominally identical wind turbine drivetrains, both in industrial test setups and during field operations, posing challenges to compliance with noise emission standards.
Bart De Smet, Jordi Marco I. Jordan, Bart Blockmans, Philip Becht, Nico De Bie, Frank Naets   +5 more
doaj   +1 more source

A DNN-Based Surrogate Constitutive Equation for Geometrically Exact Thin-Walled Rod Members

Computation
Kinematically exact rod models were a major breakthrough to evaluate complex frame structures undergoing large displacements and the associated buckling modes.
Marcos Pires Kassab, Eduardo de Morais Barreto Campello, Adnan Ibrahimbegovic   +2 more
doaj   +1 more source

Reduced chemistry for butanol isomers at engine-relevant conditions

, 2017
Butanol has received significant research attention as a second-generation biofuel in the past few years. In the present study, skeletal mechanisms for four butanol isomers were generated from two widely accepted, well-validated detailed chemical kinetic
Brady, Kyle B., Hui, Xin, Niemeyer, Kyle E., Sung, Chih-Jen   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Surrogate-Assisted Symbolic Time-Series Discretization Using Multi-Breakpoints and a Multi-Objective Evolutionary Algorithm

Mathematical and Computational Applications
The enhanced multi-objective symbolic discretization for time series (eMODiTS) method employs a flexible discretization scheme using different value cuts for each non-equal time interval, which incurs a high computational cost for evaluating each ...
Aldo Márquez-Grajales, Efrén Mezura-Montes, Héctor-Gabriel Acosta-Mesa, Fernando Salas-Martínez   +3 more
doaj   +1 more source

Considerations of Accuracy and Uncertainty with Kriging Surrogate Models in Single-Objective Electromagnetic Design Optimization

, 2007
The high computational cost of evaluating objective functions in electromagnetic optimal design problems necessitates the use of cost-effective techniques.
Hawe, G., Sykulski, J.K.
core  

Metamodel-based importance sampling for the simulation of rare events

, 2011
In the field of structural reliability, the Monte-Carlo estimator is considered as the reference probability estimator. However, it is still untractable for real engineering cases since it requires a high number of runs of the model.
Deheeger, F., Dubourg, V., Sudret, B.
core   +2 more sources

Surrogate Residuals for Discrete Choice Models

Journal of Computational and Graphical Statistics, 2020
Discrete choice models (DCMs) are a class of models for modeling response variables that take values from a set of alternatives. Examples include logistic regression, probit regression, and multinomial logistic regression. These models are also referred together as generalized linear models. Although there exist methods for the goodness of fit of DCMs,
Chao, Cheng, Rui, Wang, Heping, Zhang
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source