Results 91 to 100 of about 217,450 (265)

Fatigue Damage Assessment of Offshore Wind Turbine Foundation Under Coupled Wind–Wave Loading Using Surrogate Modeling

Energies
This study develops an efficient fatigue prediction framework for offshore wind turbine (OWT) monopile foundations under coupled wind–wave conditions using four surrogate models: XGBoost, Random Forest (RF), Support Vector Regression (SVR), and Gaussian ...
Chong Dai, Jinhai Zhao, Rui Sun
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Computational Optimisation of Urban Design Models: A Systematic Literature Review

Urban Science
The densification of urban spaces globally has contributed to a need for design tools supporting the planning of more sustainable, efficient, and liveable cities.
JingZhi Tay, Frederick Peter Ortner, Thomas Wortmann, Elif Esra Aydin   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Reducing Tolerance‐Induced Spread on Transmission Error in Planetary Gear Stages Using Monte Carlo Simulations and Surrogate Models Acquired From a Design of Experiments Approach

Wind Energy
Significant variations in tonality levels are frequently observed among nominally identical wind turbine drivetrains, both in industrial test setups and during field operations, posing challenges to compliance with noise emission standards.
Bart De Smet, Jordi Marco I. Jordan, Bart Blockmans, Philip Becht, Nico De Bie, Frank Naets   +5 more
doaj   +1 more source

Assessment of Surrogate Models for Research on Resistance and Deformation of Repairs of the Human Meniscal Roots: Porcine or Older Human Models?

Applied Sciences
Meniscal root repair is not routinely recommended for patients over 75 years old, yet surrogate age-unrestricted human or porcine models are used for its evaluation.
Alejandro Peña-Trabalon, Ana Perez-Blanca, Salvador Moreno-Vegas, M. Belen Estebanez-Campos, Maria Prado-Novoa   +4 more
doaj   +1 more source

Conditional Denoising Model as a Physical Surrogate Model

CoRR
Surrogate modeling for complex physical systems typically faces a trade-off between data-fitting accuracy and physical consistency. Physics-consistent approaches typically treat physical laws as soft constraints within the loss function, a strategy that frequently fails to guarantee strict adherence to the governing equations, or rely on post ...
Afonso, José, Viegas, Pedro, Ventura, Rodrigo, Guerra, Vasco   +3 more
openaire   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Multi-Objective Optimization of Building Energy Consumption: A Case Study of Temporary Buildings on Construction Sites

Buildings
Building energy consumption management significantly impacts energy efficiency, environmental effects, and economic benefits throughout a building’s life cycle.
Xiaohui Guo, Yuanfeng Wang, Yinshan Liu, Lei Fan, Shaoqin Xue, Chengcheng Shi, Lei Pan, Boqun Zhang, Liping Wang, Xinlei Chang   +9 more
doaj   +1 more source