Results 81 to 90 of about 223,298 (311)

Surrogate and Hybrid Models for Control [PDF]

, 2019
With access to fast computers and efficient machine learning tools, it is of interest to use machine learning to develop surrogate models from complex physics-based models. Next, a hybrid model is a combination model where a data driven model is built to
Bernt Lie, Lie, Bernt
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Intelligent Digital Rock Physics: Advances and Perspectives from Imaging Reconstruction to Pore-Scale Multiphase Flow Simulation

Applied Sciences
In characterizing unconventional reservoirs, conventional Digital Rock Physics (DRP) has long been constrained by three fundamental bottlenecks: the trade-off between imaging resolution and field of view, challenges in reconstructing multiscale pore ...
Xue Li, Lin Zhu, Feng Gao, Xin Liang, Zhengzheng Cao   +4 more
doaj   +1 more source

Meta-Model Framework for Surrogate-Based Parameter Estimation in Dynamical Systems

IEEE Access, 2019
The central task in modeling complex dynamical systems is parameter estimation. This task is an optimization task that involves numerous evaluations of a computationally expensive objective function.
Ziga Luksic, Jovan Tanevski, Saso Dzeroski, Ljupco Todorovski   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reusable surrogate models for distillation columns

Computers & Chemical Engineering
Surrogate modeling is a powerful methodology in chemical process engineering, frequently employed to accelerate optimization tasks where traditional flowsheet simulators are computationally prohibitive. However, the state-of-the-art is dominated by surrogate models trained for a narrow range of fixed chemical systems and operating conditions, limiting ...
Martin Bubel, Tobias Seidel, Michael Bortz   +2 more
openaire   +2 more sources

Toward Reusable Surrogate Models: Graph-Based Transfer Learning on Trusses

, 2022
Surrogate models have several uses in engineering design, including speeding up design optimization, noise reduction, test measurement interpolation, gradient estimation, portability, and protection of intellectual property.
Mueller, Caitlin, Whalen, Eamon
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Considerations of Accuracy and Uncertainty with Kriging Surrogate Models in Single-Objective Electromagnetic Design Optimization

, 2007
The high computational cost of evaluating objective functions in electromagnetic optimal design problems necessitates the use of cost-effective techniques.
Hawe, G., Sykulski, J.K.
core