Results 91 to 100 of about 18,445 (350)

"دورِ جدید میں کرائے کی ماں( Surrogate Mothering) کا تصور اور اسلامی نقطہ نظر The Concept of Surrogate Mother in the modern world in the Islamic Perspective "

open access: yesالإيضاح, 2014
Artificial insemination is a means of attaining pregnancy not involving sexual intercourse. A couple having trouble getting pregnant can benefit from the exact timing and placement of the sperm. It can overcome instances where a woman's immune system can
ڈاکٹر الطاف حسین لنگڑیال   +1 more
doaj  

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

open access: yesAdvanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian   +5 more
wiley   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

open access: yesAdvanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo   +3 more
wiley   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

open access: yesAdvanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang   +5 more
wiley   +1 more source

PROTECTION OF HUMAN RIGHTS IN THE CONTEXT OF THE DEVELOPMENT OF BIOETHICS AND GENOMICS (THEMATIC REVIEW OF THE INTERNATIONAL ROUND TABLE)

open access: yesRUDN Journal of Law, 2019
The article presents a description of the main theses of reports and presentations during the thematic meeting in the framework of an interdisciplinary group of scientific experts and students of law schools from Russia and Italy.
Elena N Trikoz
doaj   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

open access: yesAdvanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang   +21 more
wiley   +1 more source

Review of: The Ethics of Reproductive Technology (Kenneth D. Alpern ed., Oxford University Press 1992) [PDF]

open access: yes, 1994
Review of: The Ethics of Reproductive Technology (Kenneth D. Alpern ed., Oxford University Press 1992). Additional readings, glossary, introduction, notes, preface. LC 92-8252; ISBN 0-19-507435-1. [370 pp. Paper $19.95.
Ferber, Rochelle S.
core   +2 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

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