Results 51 to 60 of about 479,142 (302)

Principle and technology of step strengthening control of soft rock argillization roadway in coal mine

Meitan xuebao
The sedimentary rock strata of the coal measure are generally characterised by significant argillity, high water content and weak lithology. The problem of controlling the stability of the surrounding rock in soft rock argillation roadways has become ...
Guichen LI, Haoran HAO, Yuantian SUN, Jinghua LI, Sen YANG, Zeyu SHAO, Xiaofang WO   +6 more
doaj   +1 more source

Stress Relief and Support for Stability of Deep Mining Roadway with Thick Top Coal in Hujiahe Coal Mine with the Risk of Rock Burst

Shock and Vibration, 2021
Rock burst is a typical dynamic disaster in deep underground coal mining. Based on the support problems of the deep roadways in fully mechanized caving face 401111 of Hujiahe Coal Mine suffering from rock burst in Shaanxi Province of China, the failure ...
Wenjing Liu, Deyu Qian, Xingguo Yang, Sujian Wang, Jinping Deng, Qi Cui, Zexiang Li   +6 more
doaj   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Proposal to look for an up/down asymmetry in atmospheric neutrinos beyond Multi-GeV region with existing experimental data [PDF]

, 1999
We discuss a possible test of neutrino oscillation hypothesis by proposing the combined analysis of high energy atmospheric neutrino induced muon events that have been detected around horizontal direction in the Kolar Gold Field (KGF) underground site ...
Francesco Vissani, Krishnaswamy, Lipari, Lipari, Miyake, Shashikant R. Dugad   +5 more
core   +2 more sources

Generalization of trends in the influence of geomechanics factors on the choice of operation modes for the fastening system in the preparatory mine workings [PDF]

, 2000
Purpose. Substantiation of the mechanism of loading the preparatory mine working support to optimize its deformation-strength characteristics based on the calculation of the stress-strain state of the “massif – support” system.
Chervatiuk, V, Husiev, O, Kovalevska, I, Snihur, V, Zhuravkov, M   +4 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Numerical Simulation Based Targeting of the Magushan Skarn Cu-Mo Deposit, Middle-Lower Yangtze Metallogenic Belt, China [PDF]

, 2019
The Magushan Cu–Mo deposit is a skarn deposit within the Nanling–Xuancheng mining district of the Middle-Lower Yangtze River Metallogenic Belt (MLYRMB), China.
Dai, Wenqiang, Hu, Xunyu, Jowitt, Simon M., Li, Xiaohui, Li, Yue, Ord, Alison, Ye, Rui, Yuan, Feng, Zhou, Taofa   +8 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source