Results 71 to 80 of about 480,494 (299)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Field investigations of high stress soft surrounding rocks and deformation control

Journal of Rock Mechanics and Geotechnical Engineering, 2015
AbstractField investigations of high stress soft rock deformations show that the high stress soft rock roadway can slide with large deformation. Severe extrusion and floor heave can also be subsequently observed. The supported roadway can be locally damaged or completely fail, where the floor has a large deformation and/or is seriously damaged.
Weijian Yu, Weijun Wang, Xinyuan Chen, Shaohua Du   +3 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting [PDF]

, 2019
Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk cells migrate collectively into the extracellular matrix while preserving cell-cell junctions, forming patent ...
Chen, Christopher S., Choi, Colin, Dong, Li, Eyckmans, Jeroen, Howes, Caroline, King, Jessica, Mirabella, Teodelinda, Oberai, Assad, Stapleton, Sarah, Yang, Jinling, Yoon, Christine   +10 more
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Study on Failure Mechanism and Control Technology of Roadway Surrounding Rock under Complex Occurrence Coal Seam

Geofluids, 2022
Aiming at the characteristics of large deformation and long deformation time under the mining influence of the 2254 east floor roadway surrounding rock, which under the condition of complex coal occurrence in Jiahe Mine.
Hai Wu, Jiaren Chen, Xu Gao, Tao Ling, Xuan Zhang, Qian Jia   +5 more
doaj   +1 more source

Performance monitoring and analysis of a yield-control support system in squeezing rock [PDF]

, 2010
ISBN 978-0-415-58654-
Barla, Giovanni Battista, Bonini, Mariacristina, Semeraro, Martino   +2 more
core  

Simulation of subseismic joint and fault networks using a heuristic mechanical model [PDF]

, 2017
Flow simulations of fractured and faulted reservoirs require representation of subseismic structures about which subsurface data are limited. We describe a method for simulating fracture growth that is mechanically based but heuristic, allowing for ...
Casini, G, Gillespie, P, Iben, H, O'Brien, JF   +3 more
core   +1 more source

Latest progress on study of stability control of roadway surrounding rocks subjected to rock burst

Procedia Earth and Planetary Science, 2009
AbstractRock burst has caused tremendous hazards in coal mining. Usually, it can cause roof falling suddenly, sometimes even closing and jamming abruptly; so it has become one of the three most difficult problems of deep mining in the world. The authors discussed the present study in this field at home and abroad and introduced the latest progress ...
Gao, Ming-shi, Dou, Lin-ming, Xie, Yao-she, Gao, Jie, Zhang, Li-sheng   +4 more
openaire   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source