Results 51 to 60 of about 10,848,381 (289)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Principle and technology of step strengthening control of soft rock argillization roadway in coal mine

Meitan xuebao
The sedimentary rock strata of the coal measure are generally characterised by significant argillity, high water content and weak lithology. The problem of controlling the stability of the surrounding rock in soft rock argillation roadways has become ...
Guichen LI, Haoran HAO, Yuantian SUN, Jinghua LI, Sen YANG, Zeyu SHAO, Xiaofang WO   +6 more
doaj   +1 more source

Research on failure mechanism and control measures of surrounding rock in large section raise shaft construction chamber

Meikuang Anquan, 2022
Aiming at the problem of serious deformation and failure of large section chamber surrounding rock, taking the large section reverse shaft construction chamber of Lijiahao Mine as the research background, using the research methods of numerical ...
LI Jianhua, XIE Fuxing, CHEN Kai, JING Guoye, WANG Yongfeng, ZHOU Ming   +5 more
doaj   +1 more source

Investigation on Deformation and Failure Characteristics and Stability Control of Soft Rock Roadway Surrounding Rock in Deep Coal Mine

, 2011
Numerical simulation and field measurement were carried out to investigate into laws of deformation and movement and the evolving characteristics of the plastic region around the roadway based on engineering conditions of deep soft rock roadway in ...
Ju Cai Chang, Guang Xiang Xie
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Stress Relief and Support for Stability of Deep Mining Roadway with Thick Top Coal in Hujiahe Coal Mine with the Risk of Rock Burst

Shock and Vibration, 2021
Rock burst is a typical dynamic disaster in deep underground coal mining. Based on the support problems of the deep roadways in fully mechanized caving face 401111 of Hujiahe Coal Mine suffering from rock burst in Shaanxi Province of China, the failure ...
Wenjing Liu, Deyu Qian, Xingguo Yang, Sujian Wang, Jinping Deng, Qi Cui, Zexiang Li   +6 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Time-Varying Response Analysis of Surrounding Rock Construction Mechanics of a Double-Arch Tunnel without a Middle Pilot Tunnel and Suggestions for Tunnel Construction

, 2022
This research carries out the model test and numerical simulation, studying the time-varying response regularity of surrounding rock construction mechanics.
Caijin Xie, Junying Rao, Tiejun Tao
core   +1 more source

Functionalizing Micro‐to‐Mesoscopic Electrode Architectures for Regulating Electron Transfer Behaviors in Electrocatalysis

Advanced Functional Materials, EarlyView.
A systematic review is conducted to assess the influence of electrode architecture across micro‐ to mesoscopic length scales on electron‐transfer pathways in electrocatalysis. We discuss the structure‐activity relationships in electrocatalytic applications, including resource recovery and environmental remediation, and provide cost‐effective, efficient
Manshu Zhao, Jiaojiao Zhang, Shideng Yuan, Xinmeng Yu, Keming Wan, Xiaoguang Duan, Zhining Wang   +6 more
wiley   +1 more source