Results 41 to 50 of about 19,664 (248)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Study on the Convergence of Surrounding Rock in Shallow Buried Unsymmetrical Pressure Tunnel Construction

Journal of Physics: Conference Series, 2023
Abstract In order to study the evolution law of tunnel convergence deformation during the construction of shallow buried unsymmetrical pressure tunnel, the deformation characteristics and evolution law of shallow buried unsymmetrical pressure tunnel during the three-step construction method are studied based on the background of Qingshui
Yu Hu, Genzhong Wang, Min Zhou, Wangjing Hu, Jin Ye, Wenxue Gao   +5 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mechanical mechanism and morphological characteristics of fracture range formation in surrounding rock of soft rock roadway

Meitan xuebao
After the excavation of the roadway, the broken expansion and shear expansion of the surrounding rock along the crack surface are the important reasons for the large deformation of the surrounding rock, and the broken expansion and shear expansion of the
Yujie MA, Weijun WANG, Chao YUAN, Hai WU, Xinyu TIAN, Shihai SHU, Sha GE   +6 more
doaj   +1 more source

Giant Magnetic Coercivity Driven by Spin‐Bag Ferromagnetism in Epitaxial Sr3YCo4O10+δ Films with Engineered 2D Oxygen Vacancy Ordering

Advanced Functional Materials, EarlyView.
A giant magnetic coercivity and a vertical shift of hysteresis loops are demonstrated in Sr3YCo4O10+δ epitaxial films. The hard magnetic behavior originates from ferromagnetic spin bags stabilized within a long‐range ordered oxygen‐vacancy structure.
Yanbin Chen, Roger Guzman, Xiaomin Jia, Jialu Wu, Xing Xu, Li Sun, Jinbo Pan, Shixuan Du, Myung‐Hwan Whangbo, Wu Zhou, Jing Ma, Ce‐wen Nan, Chonglin Chen   +12 more
wiley   +1 more source

Experimental Study on the Failure Mechanism of Tunnel Surrounding Rock under Different Groundwater Seepage Paths

Geofluids, 2021
The influence of groundwater on tunnel engineering is very complicated. Due to the complexity of water flow water pressure transfer and uncertain defects in the stratum, all of which are key factors with regard to the design of tunnel engineering ...
Yingchao Wang, Yang Liu, Yongliang Li, Wen Jiang, Yueming Wang   +4 more
doaj   +1 more source

Experiment Study on Mechanical Evolution Characteristics of Coal and Rock under Three-Dimensional Triaxial Stress

Applied Sciences, 2022
The surrounding rock is in a complex stress environment and its mechanical behavior is also complex, especially after the excavation of the coal seam, the phenomenon of stress release of surrounding rock often occurs.
Yabin Tao, Han Du, Ruixin Zhang, Jianzhao Feng, Zhiyun Deng   +4 more
doaj   +1 more source

From Geometry to Function: Programmable Mechanical Response in 3D‐Printed Adipose‐Inspired Soft Metamaterials

Advanced Functional Materials, EarlyView.
Geometry‐driven design of soft cellular metamaterials is systematically investigated by combining experiments, finite element modeling, and statistical prediction. The study quantifies how unit cell geometry and material properties govern stiffness, instability, densification, and energy absorption.
Alice Berardo, Gianmarco Dolino, Damiano Coato, Paolo Gargiulo, Emanuele Luigi Carniel   +4 more
wiley   +1 more source

Functionalizing Micro‐to‐Mesoscopic Electrode Architectures for Regulating Electron Transfer Behaviors in Electrocatalysis

Advanced Functional Materials, EarlyView.
A systematic review is conducted to assess the influence of electrode architecture across micro‐ to mesoscopic length scales on electron‐transfer pathways in electrocatalysis. We discuss the structure‐activity relationships in electrocatalytic applications, including resource recovery and environmental remediation, and provide cost‐effective, efficient
Manshu Zhao, Jiaojiao Zhang, Shideng Yuan, Xinmeng Yu, Keming Wan, Xiaoguang Duan, Zhining Wang   +6 more
wiley   +1 more source

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source