Results 31 to 40 of about 16,431 (261)

Deformation Mechanism and Support Technology of Deep and High-Stress Soft Rock Roadway

Advances in Civil Engineering, 2021
In this study, the analysis and control of stability of surrounding rock in deep fractured soft rock roadway located in the underground mine of Jinfeng gold mine in Guizhou Province, China, has been investigated.
Lujing Zheng, Yujun Zuo, Yafei Hu, Wei Wu   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Theoretical analysis of grouting reinforcement for surrounding rock of deep shaft based on stability and water inflow control

Frontiers in Earth Science, 2023
To address the challenge of designing grouting reinforcement in a deep shaft to control water, this study established an elastic-plastic analytical formula for the grouted rock surrounding a shaft under the combined action of thermal, hydraulic, and ...
Peng Xiang, Hong Guang Ji, Guang Quan Zhang, Wen Guang Li   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Case Study on the Stability Control of Broken Surrounding Rock in Roadway Excavation on the Edge of a Collapsed Stope Area

Advances in Civil Engineering, 2021
Predicting and controlling the collapse of surrounding rock (especially broken rock masses) in underground chambers is an important topic in mining and geotechnical engineering.
Yabin Wu, Jianhua Hu, Chengyu Xie, Dongping Shi   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Analysis on surrounding rock masses� stabilities for underground cavern group [PDF]

Proceedings of the 2015 4th International Conference on Computer, Mechatronics, Control and Electronic Engineering, 2015
Surrounding rock masses' stabilities of cavities and crane beams of the hydropower station were studied using FLAC 3D. Results show that, due to the large excavation span and height, the main powerhouse and tail water hole have larger plastic zones after the excavation, and the same as 1 # unit and 2 # unit affected by the alteration belt; after the ...
Yun-juan Chen, Chao-qun Sun, Shu-guang Song   +2 more
openaire   +1 more source

Multimodal Data‐Driven Microstructure Characterization

Advanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang, Santiago Benito, Özge Özgün, Sebastian Weber, Markus Stricker   +4 more
wiley   +1 more source

Pressure relief for drilling (trenching) and support technology in deep soft rock tunnels

Frontiers in Earth Science
Controlling surrounding rock stability in deep soft rock tunnels solely by increasing the support strength is challenging. The key areas where the surrounding rock of a roadway is prone to “instability” should be treated with comprehensive measures, such
Yang Ling, Xu Ying
doaj   +1 more source