Results 91 to 100 of about 2,371,679 (305)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Primary leptomeningeal histiocytic lymphoproliferative disorder associated with SARS-CoV-2 brain infection in k18-hACE2 mouse: a case report

Laboratory Animal Research
Background Histiocytic proliferative disorders in the central nervous system are rare, and their potential association with viral infections remains largely unexplored.
Néstor Porras, Lidia Sánchez-Morales, Marta Pérez-Sancho, Lucas Domínguez, Antonio Rodríguez-Bertos   +4 more
doaj   +1 more source

National Near Real-Time Vaccine Effectiveness Against COVID-19 Severe Outcomes Using the Screening Method Among Older Adults Aged ≥50 Years in Canada

Vaccines
Background/Objectives: It is critical to monitor real-world COVID-19 vaccine effectiveness (VE) in older adults, as they have been identified as a priority group for vaccination.
Robert MacTavish, Andreea Slatculescu, Dylan Ermacora, Katarina Vukovojac, Tanner Noth, Natalie Ward, Kathleen Laskoski, Daniela Fleming, Baanu Manoharan, Julie Laroche, Aissatou Fall   +10 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Influenza surveillance

Postępy Higieny i Medycyny Doświadczalnej, 2016
Influenza surveillance was established in 1947. From this moment WHO (World Health Organization) has been coordinating international cooperation, with a goal of monitoring influenza virus activity, effective diagnostic of the circulating viruses and informing society about epidemics or pandemics, as well as about emergence of new subtypes of influenza ...
Karolina, Bednarska, Ewelina, Hallmann-Szelińska, Katarzyna, Kondratiuk, Lidia B, Brydak   +3 more
openaire   +2 more sources

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Antemortem diagnosis of human rabies in a veterinarian infected when handling a herbivore in Minas Gerais, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2011
The Ministry of Health's National Human Rabies Control Program advocates pre-exposure prophylaxis (PEP) for professionals involved with animals that are at risk of contracting rabies.
Mariana Gontijo de Brito, Talita Leal Chamone, Fernando José da Silva, Marcelo Yohito Wada, Alexandre Braga de Miranda, Juliana Galera Castilho, Maria Luiza Carrieri, Ivanete Kotait, Francisco Leopoldo Lemos   +8 more
doaj   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Exchange trading rules, surveillance and insider trading : [draft 15 oct 2013] [PDF]

, 2013
We examine the impact of stock exchange trading rules and surveillance on the frequency and severity of suspected insider trading cases in 22 stock exchanges around the world over the period January 2003 through June 2011.
Aitken, Michael, Cumming, Douglas, Zhan, Feng   +2 more
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