Results 51 to 60 of about 2,371,679 (305)

Influenza Vaccine Effectiveness Estimates among US Department of Defense Adult Beneficiaries over Four Consecutive Influenza Seasons: A Test-Negative Design Study with Different Control Groups

Vaccines, 2021
A test-negative design study with different control groups (influenza test-negative controls, non-influenza virus positive controls, and pan-negative controls) was conducted to assess inactivated influenza vaccine effectiveness (VE) in adults aged ≥18 ...
Wenping Hu, Paul A. Sjoberg, Laurie S. DeMarcus, Anthony S. Robbins   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

THE USE OF CORRELATION ANALYSIS ON THE EXAMPLE OF INFLUENZA VACCINATION ON THE TERRITORY OF THE ROSTOV REGION

Инфекция и иммунитет, 2018
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S. S. Slis’, E. V. Kovalev, S. A. Nenadskaya, G. A. Miroshnichenko   +3 more
doaj   +1 more source

The Emergence of Big Data Policing [PDF]

, 2017
The past decade has seen both the proliferation of surveillance in everyday life and the rise of “big data.” Through extensive qualitative research focusing on the Los Angeles Police Department (LAPD), PRC faculty research associate Sarah Brayne explores
Brayne, Sarah
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Understanding the infection severity and epidemiological characteristics of mpox in the UK

Nature Communications
In May 2022, individuals infected with the monkeypox virus were detected in the UK without clear travel links to endemic areas. Understanding the clinical characteristics and infection severity of mpox is necessary for effective public health policy. The
Thomas Ward, Christopher E. Overton, Robert S. Paton, Rachel Christie, Fergus Cumming, Martyn Fyles   +5 more
doaj   +1 more source

USEFULNESS, ACCEPTABILITY, REPRESENTATIVENESS AND REACTIVITY OF COMMUNITY BASED SURVEILLANCE IN INSECURITY SETTINGS, TILLABERI REGION – NIGER

International Journal of Infectious Diseases, 2023
Intro: Insecurity in Tillaberi region in Niger is a threat to the poliomyelitis eradication achievement due to weakened public health systems. Community- Based Surveillance (CBS) is implemented since June 2017 to strengthen Acute Flaccid Paralysis (AFP ...
A.M.-E. Tchalla Abalo, K. Mugenyi, J. Magoola, H. Samba, A.H. Aboubacar, C. Na Andi Ibrahim, J.P. Six Moke, C.D. Apollo, N. Ernest, A.F. Asanji, S. Abdoulaye Seid, C.A. Zabré, N. Ayebazibwe, D. Kazambu   +13 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Can remote STI/HIV testing and eClinical Care be compatible with robust public health surveillance? [PDF]

, 2015
In this paper we outline the current data capture systems for human immunodeficiency virus (HIV) and sexually transmitted infection (STI) surveillance used by Public Health England (PHE), and how these will be affected by the introduction of novel ...
Estcourt, C, Gibbs, J, Gill, N, Harding-Esch, EM, Hughes, G, Lowndes, C, Mohammed, H, Nardone, A, Sadiq, ST, Sonnenberg, P, Sutcliffe, L   +10 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source