Results 51 to 60 of about 693,758 (252)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Understanding the infection severity and epidemiological characteristics of mpox in the UK

Nature Communications
In May 2022, individuals infected with the monkeypox virus were detected in the UK without clear travel links to endemic areas. Understanding the clinical characteristics and infection severity of mpox is necessary for effective public health policy. The
Thomas Ward, Christopher E. Overton, Robert S. Paton, Rachel Christie, Fergus Cumming, Martyn Fyles   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples

eLife
Artemisinin partial resistance (ART-R) in Plasmodium falciparum is a major challenge to malaria control globally. Over the last two decades, ART-R has spread widely across Southeast Asia, undermining public health strategies and hindering elimination. As
Andrew J Balmer, Nina FD White, Eyyüb S Ünlü, Chiyun Lee, Richard D Pearson, Jacob Almagro-Garcia, Cristina Ariani   +6 more
doaj   +1 more source

Influence of SARS-CoV-2 surveillance outputs produced by the UK health security agency (UKHSA) outbreak surveillance team on decision-making by local stakeholders

BMC Public Health, 2023
Background The UK Health Security Agency (UKHSA) COVID-19 Outbreak Surveillance Team (OST) was established in June 2020 to provide Local Authorities (LAs) in England with surveillance intelligence to aid their response to the SARS-CoV-2 epidemic. Reports
Katriina Willgert, Jo Hardstaff, Stephanie Shadwell, Alex Bhattacharya, Paula Blomquist, Roberto Vivancos, Ian Simms   +6 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Quality assessment of malaria microscopic diagnosis at the Aristide Le Dantec University Hospital of Dakar, Senegal, in 2020

BMC Research Notes
Background Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation.
Mamane N. Garba, Awa B. Dème, Khadim Diongue, Younousse Diédhiou, Amadou M. Mbaye, NDèye M. Dia, N’Dèye A. Seck, Daba Zoumarou, Lamine Ndiaye, Mamadou S. Yade, Baba Dièye, Aita Sène, Abdoulaye Tine, Mariama Touré, Nogaye Gadiaga, Awa Fall, Bassirou Ngom, Djiby Sow, Aliou Ndiaye, Astou Keita, Mame F. Ndiaye, Jules F. Gomis, Nana F. Diop, Guète Diallo, Ibrahima M. Ndiaye, Elhadj M. Ba, Omar Bitèye, Cheikh Ndiaye, Fama S. D. Mbodji, Pape O. Ndiaye, Tolla Ndiaye, Amy Gaye, Mouhamad Sy, Yaye D. Ndiaye, Mame C. Seck, Mouhamadou Ndiaye, Aida S. Badiane, Mamadou A. Diallo, Daouda Ndiaye   +38 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 43 2003 [PDF]

, 2003
GP consultations rates for influenza-like illness increased during week 43 in Ireland. Influenza activity levels are higher than previously recorded for this time of year (the influenza surveillance scheme began in October 2000).
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
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