Results 61 to 70 of about 2,371,679 (305)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mobile cameras as new technologies of surveillance? How citizens experience the use of mobile cameras in public nightscapes. [PDF]

, 2012
In Surveillance Studies the terms ‘sousveillance’ and ‘inverse surveillance’ describe forms of surveillance that have a bottom-up and democratic character.
Oudshoorn, N.E.J., Timan, T.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Quality assessment of malaria microscopic diagnosis at the Aristide Le Dantec University Hospital of Dakar, Senegal, in 2020

BMC Research Notes
Background Following WHO guidelines, microscopy is the gold standard for malaria diagnosis in endemic countries. The Parasitology-Mycology laboratory (LPM) is the National Reference Laboratory and is currently undergoing ISO 15189 accreditation.
Mamane N. Garba, Awa B. Dème, Khadim Diongue, Younousse Diédhiou, Amadou M. Mbaye, NDèye M. Dia, N’Dèye A. Seck, Daba Zoumarou, Lamine Ndiaye, Mamadou S. Yade, Baba Dièye, Aita Sène, Abdoulaye Tine, Mariama Touré, Nogaye Gadiaga, Awa Fall, Bassirou Ngom, Djiby Sow, Aliou Ndiaye, Astou Keita, Mame F. Ndiaye, Jules F. Gomis, Nana F. Diop, Guète Diallo, Ibrahima M. Ndiaye, Elhadj M. Ba, Omar Bitèye, Cheikh Ndiaye, Fama S. D. Mbodji, Pape O. Ndiaye, Tolla Ndiaye, Amy Gaye, Mouhamad Sy, Yaye D. Ndiaye, Mame C. Seck, Mouhamadou Ndiaye, Aida S. Badiane, Mamadou A. Diallo, Daouda Ndiaye   +38 more
doaj   +1 more source

Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples

eLife
Artemisinin partial resistance (ART-R) in Plasmodium falciparum is a major challenge to malaria control globally. Over the last two decades, ART-R has spread widely across Southeast Asia, undermining public health strategies and hindering elimination. As
Andrew J Balmer, Nina FD White, Eyyüb S Ünlü, Chiyun Lee, Richard D Pearson, Jacob Almagro-Garcia, Cristina Ariani   +6 more
doaj   +1 more source

The need to improve implementation and use of lifestyle surveillance systems for planning prevention activities: an analysis of the Italian Regions [PDF]

, 2016
Objectives: To describe the level of use of lifestyle surveillance systems in Italy and to identify predictors of their use by the Italian Regions for planning and monitoring purposes.
D'Andrea, Elvira, DE VITO, Corrado, Marzuillo, Carolina, Massimi, Azzurra, Rosso, Annalisa, Unim, BRIGID ANDOUNIMYE, Villari, Paolo   +6 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

AIDS Surveillance in Africa [PDF]

, 1991
Surveillance of the AIDS pandemic in Africa has always posed formidable problems for epidemiologists. Diagnostic accuracy-according to the case definitions for AIDS used in industrialised countries-is impossible to achieve in all but a few places with ...
BIGGAR, R.J., KILLEWO, J., NICOLL, A.
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source