Results 231 to 240 of about 4,921,450 (294)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Preoperative planning software as a digital health tool in orthopedics: Surgeon-reported benefits in shoulder arthroplasty. [PDF]

Surg Open Sci
Reynier M, Shank S, Venegoni M, Regling M, de Gast A.   +4 more
europepmc   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Survey of practices around the measurement and replacement of calcium in paediatric major trauma. [PDF]

BMJ Paediatr Open
Hibberd O, Ranaweera M, Karageorgos S, Priddis K, Nijman RG, Tagg A, Hall D, Roland D.   +7 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Employee preferences in health plan design: results from a national survey. [PDF]

Health Aff Sch
Kaplan RM, Nikolov MC, Pfeffer J, Milstein A, Singer SJ.   +4 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

How Are Deprescribing Clinical Practice Guidelines Disseminated and Implemented? A Cross-Sectional Study of International Organisational Stakeholders. [PDF]

Basic Clin Pharmacol Toxicol
Cheng CHJ, Gnjidic D, Mathieson S, Farrell BJ, McCarthy LM, Thompson W, Schneider CR.   +6 more
europepmc   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Defining Recurrent Lumbar Disc Herniation (RLDH): An International Survey Study. [PDF]

Global Spine J
Harhangi JS, Boeykens A, Dos Santos Rubio EJ, Morgenstern C, Burkhardt BW, Datar G, Lewandrowski KU, Harhangi BS.   +7 more
europepmc   +1 more source