Results 151 to 160 of about 206,801 (259)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exploring Students' Perceptions and Usage of Artificial Intelligence in Supporting Mental Health: A Preliminary Study in Higher Education in Qatar. [PDF]

Healthcare (Basel)
ElBarazi AS, Mohamed H, Nasser R.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Healthcare Provider Awareness and Perspectives on Obesity: A Survey Across Medical Specialties. [PDF]

Obes Sci Pract
Alawadi F, Bhatti R, Hafidh K, McGowan B, Rai S, Koechlin A, Mohseni A, Tangi F, Batterham R, Suliman SGI.   +9 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Breaking Bad News: The Perspective and Experience of Women with Gynecological Cancer (Results of the NOGGO-Expression XX Survey). [PDF]

Curr Oncol
Igde E, Oskay-Özcelik G, Vasiljeva J, Karaman M, Fechner S, Pirmorady Sehouli A, Sehouli J.   +6 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Population expectations of primary care quality in 18 countries: a cross-sectional analysis of data from the People's Voice Survey.

Lancet Prim Care
Lewis TP, Sabwa S, Breda J, Carai S, Clarke-Deelder E, Doubova SV, Fink G, Garcia PJ, Garcia-Elorrio E, Lee HY, Mohan S, Naidoo I, Oh J, Okiro EA, Tadele A, Tarricone R, Ungureanu MI, Wang X, Xu DR, Kruk ME.   +19 more
europepmc   +1 more source

Community perspectives on physicians' roles in nutritional care: a survey from Northeast and Central Pennsylvania. [PDF]

Prev Med Rep
Johnson H, Kunitsky O, Mamillapalli S, Waite G, Lobo S.   +4 more
europepmc   +1 more source

Inflation Expectations and Survey Design

Inflation Expectations and Survey Design
We examine whether inflation expectations obtained by open- and closed-ended questions lead to different inflation expectations through a randomized controlled trial. We find that different questionnaires measure significantly different inflation expectations, especially in the short term.
openaire