Results 191 to 200 of about 89,205 (311)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Review of Survey activities 2015: Miocene deposits at Silkeborg, Jylland, and their influence on hydrology [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2016
P.R. Jakobsen, E.S. Rasmussen, K. Dybkjær , J. Kidmose   +3 more
doaj  

Survey on Patient Organisations Research Priorities

Survey on patient organisation research priorities.
openaire   +1 more source

Drivers of youth mental health and wellbeing: a large-scale cross-sectional study in Morocco. [PDF]

BMJ Open
Bnimoussa J, Bouaddi O, El Badisy I, Khalis M.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Developing internationally agreed core indicators for surveillance of preconception health: protocol for a consensus study. [PDF]

PLoS One
Schoenaker D, Hall J, Al-Jayyousi GF, Borges ALV, Boua PR, Chan JKY, Chitashvili T, Delbaere I, Demidova A, Fikadu K, Fisher S, Hazra A, James S, Ku CW, Maeda E, Memon Z, Munblit D, Mulders A, Murira Z, Norman WV, Ogle A, Sethi V, Shahbic HI, Kakoly NS, Verbiest S, Stephenson J, International Core Indicators for Preconception Health and Equity (iCIPHE) Alliance.   +26 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Review of Survey activities 2016: Nitrate transport pathways in riparian zones of the Hagens Møllebæk catchment, northern Denmark [PDF]

Geological Survey of Denmark and Greenland Bulletin, 2017
B. Nilsson, A.L. Højberg, P. Jensen
doaj  

Nutritionists and Dietitians as Key Actors in Local Food Systems: A Systems-Based Social Network Analysis. [PDF]

J Hum Nutr Diet
Pickles S, Stefoska-Needham A, Cullerton K, Kent K, Charlton K.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source