Results 191 to 200 of about 2,750,053 (267)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Center for Species Survival Nigeria launches programme of work

Oryx
Bello A. Danmallam, Kira Mileham, Samuel T. Ivande, Mayerlin Ramos, Talatu Tende, Adams A. Chaskda   +5 more
doaj   +1 more source

A Retrospective Study of a Postoperative Inflammation-Based Score for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy. [PDF]

Cancer Manag Res
Yang Q, Li J, Ding L, Feng L, Chen S, Liu Y, Zhou Z.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A major victory in the effort to end the online, ornamental trade in bats

Oryx
Joanna L. Coleman, Joe Chun-Chia Huang, Tigga Kingston, Benjamin P.Y.-H. Lee, Joy M. O'Keefe, Nistara Randhawa, Abigail L. Rutrough, Chris R. Shepherd, Vu Dinh Thong, Susan M. Tsang   +9 more
doaj   +1 more source

Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002). [PDF]

Commun Med (Lond)
Yang DL, Qin C, Peng N, Liu SP, Yu YQ, Nong JL, Zeng FJ, Su Z, Yang YY, Yang FQ, Li MJ, Wu MS, Wang XY, Liang YR, Li FX, Chen SC, Lai YC, Pang QQ, Zhong TM, Yan YH, Zhang YY, Ye L, Dong XF, Li WF, Liu J, Yao HB, Wu PS, Mao XS, Ou JJ, Chen YZ, Wang GD, Chen K, Deng ZJ, Su JY, Qiu GG, Liu ZD, Wang JM, Zhang Y, Liang XM, Xiang BD, Ma L, Zhong JH, GUIDANCE investigators.   +42 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

IUCN Species Survival Commission Sponge Specialist Group

Oryx
Joana Xavier, Toufiek Samaai, Monika Böhm, Coralie Palmer   +3 more
doaj   +1 more source