Results 71 to 80 of about 4,850,533 (302)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma

Annals of Gastroenterological Surgery
Aim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC).
Yosuke Namba, Masahiro Ohira, Yuki Imaoka, Michinori Hamaoka, Masakazu Hashimoto, Takashi Onoe, Daisuke Takei, Koichi Oishi, Megumi Yamaguchi, Tomoyuki Abe, Takeshi Tadokoro, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Shintaro Kuroda, Hiroyuki Tahara, Tsuyoshi Kobayashi, Kentaro Ide, Hideki Ohdan   +19 more
doaj   +1 more source

Explainable Survival Analysis of Censored Clinical Data Using a Neural Network Approach

BioMedInformatics
Survival analysis is a statistical approach widely employed to model the time of an event, such as a patient’s death. Classical approaches include the Kaplan–Meier estimator and Cox proportional hazards regression, which assume a linear relationship ...
Lisa Anita De Santi, Francesca Orlandini, Vincenzo Positano, Laura Pistoia, Francesco Sorrentino, Giuseppe Messina, Maria Grazia Roberti, Massimiliano Missere, Nicolò Schicchi, Antonino Vallone, Maria Filomena Santarelli, Alberto Clemente, Antonella Meloni   +12 more
doaj   +1 more source

An Analytic Approach to the Cox Proportional Hazards Model for Estimating the Lifespan of Cutting Tools

Journal of Manufacturing and Materials Processing, 2020
The machining industry raises an ever-growing concern for the significant cost of cutting tools in the production process of mechanical parts, with a focus on the replacement policy of these inserts.
Lucas Equeter, François Ducobu, Edouard Rivière-Lorphèvre, Roger Serra, Pierre Dehombreux   +4 more
doaj   +1 more source

Survival Analysis in LGD Modeling [PDF]

The paper proposes an application of the survival time analysis methodology to estimations of the Loss Given Default (LGD) parameter. The main advantage of the survival analysis approach compared to classical regression methods is that it allows ...
Jiří Witzany, Michal Rychnovský, Pavel Charamza   +2 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Risk scoring model for lung adenocarcinoma based on PD-L1 related signature reveals prognostic predictability and correlation with tumor immune microenvironment genes was constructed

Frontiers in Immunology
BackgroundImmunotherapy has recently become a hot topic in the field of oncology, with PD-L1 playing a crucial role in this area. However, the research on PD-L1 correlation prediction models is not fully understood.
Meng Li-Fei, Si-Meng Ren, Jun Wang, Wei-Jun Zhao, Jian Chen, Wen-Tao Hu   +5 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Meal Pattern Variables and 15-Year Mortality: Results from the Gothenburg H70 Birth Cohort Studies, Sweden

Food & Nutrition Research
Background: Dietary habits throughout life significantly influence health in old age; yet, little is known about the relationship between meal pattern and mortality among older adults.
Emmalee Gisslevik, Love Svanqvist, Ingmar Skoog, Lauren Lissner, Elisabet Rothenberg   +4 more
doaj   +1 more source