Results 71 to 80 of about 2,712,400 (306)
International Journal of Integrated CareIntroduction: Integrated care poses a significant challenge for healthcare policies in Japan as evaluation of hospital discharge services is limited.
Masumi Takei +3 more
doaj +1 more source
Journal of Manufacturing and Materials Processing, 2020 The machining industry raises an ever-growing concern for the significant cost of cutting tools in the production process of mechanical parts, with a focus on the replacement policy of these inserts.
Lucas Equeter +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Survival Prediction of Pediatric Leukemia under Model Uncertainty [PDF]
This dissertation addresses critical challenges in survival prediction for pediatric leukemia, particularly Acute Lymphoblastic Leukemia (ALL), by introducing novel predictive models that incorporate Bayesian principles and advanced machine learning and ...
Cui, Yuning
core
Genetic architecture of rainbow trout survival from egg to adult
, 2010 Survival from birth to a reproductive adult is a challenge that only robust individuals resistant to a variety of mortality factors will overcome. To assess whether survival traits share genetic architecture throughout the life cycle, we estimated ...
Paananen, T. +5 more
core +1 more source
Bayesian non-parametric ordinal regression under a monotonicity constraint
, 2022 Compared to the nominal scale, the ordinal scale for a categorical outcome variable has the property of making a monotonicity assumption for the covariate effects meaningful.
Saarela, Olli +2 more
core +1 more source
Annals of Gastroenterological SurgeryAim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC).
Yosuke Namba +19 more
doaj +1 more source
Explainable Survival Analysis of Censored Clinical Data Using a Neural Network Approach
BioMedInformaticsSurvival analysis is a statistical approach widely employed to model the time of an event, such as a patient’s death. Classical approaches include the Kaplan–Meier estimator and Cox proportional hazards regression, which assume a linear relationship ...
Lisa Anita De Santi +12 more
doaj +1 more source