Results 71 to 80 of about 4,846,031 (286)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Survival Analysis in LGD Modeling [PDF]

The paper proposes an application of the survival time analysis methodology to estimations of the Loss Given Default (LGD) parameter. The main advantage of the survival analysis approach compared to classical regression methods is that it allows ...
Jiří Witzany, Michal Rychnovský, Pavel Charamza   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma

Annals of Gastroenterological Surgery
Aim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC).
Yosuke Namba, Masahiro Ohira, Yuki Imaoka, Michinori Hamaoka, Masakazu Hashimoto, Takashi Onoe, Daisuke Takei, Koichi Oishi, Megumi Yamaguchi, Tomoyuki Abe, Takeshi Tadokoro, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Shintaro Kuroda, Hiroyuki Tahara, Tsuyoshi Kobayashi, Kentaro Ide, Hideki Ohdan   +19 more
doaj   +1 more source

Explainable Survival Analysis of Censored Clinical Data Using a Neural Network Approach

BioMedInformatics
Survival analysis is a statistical approach widely employed to model the time of an event, such as a patient’s death. Classical approaches include the Kaplan–Meier estimator and Cox proportional hazards regression, which assume a linear relationship ...
Lisa Anita De Santi, Francesca Orlandini, Vincenzo Positano, Laura Pistoia, Francesco Sorrentino, Giuseppe Messina, Maria Grazia Roberti, Massimiliano Missere, Nicolò Schicchi, Antonino Vallone, Maria Filomena Santarelli, Alberto Clemente, Antonella Meloni   +12 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Risk scoring model for lung adenocarcinoma based on PD-L1 related signature reveals prognostic predictability and correlation with tumor immune microenvironment genes was constructed

Frontiers in Immunology
BackgroundImmunotherapy has recently become a hot topic in the field of oncology, with PD-L1 playing a crucial role in this area. However, the research on PD-L1 correlation prediction models is not fully understood.
Meng Li-Fei, Si-Meng Ren, Jun Wang, Wei-Jun Zhao, Jian Chen, Wen-Tao Hu   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Meal Pattern Variables and 15-Year Mortality: Results from the Gothenburg H70 Birth Cohort Studies, Sweden

Food & Nutrition Research
Background: Dietary habits throughout life significantly influence health in old age; yet, little is known about the relationship between meal pattern and mortality among older adults.
Emmalee Gisslevik, Love Svanqvist, Ingmar Skoog, Lauren Lissner, Elisabet Rothenberg   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source